July 14, 1993 
Protocol Numbers: 
NCI:T92-0000 
Medicine Branch #:MB 
Clinical Center #: 
IND's: 
G-CSF: #BB2704 
Taxol: #22850 
Carboplatin: #19314 
Retroviral Mediated Transfer of the Human Multidrug Resistance Gene (MDR-1) 
into Hematopoietic Stem Cells during Autologous Transplantation after Intensive 
Chemotherapy for Metastatic Breast Cancer 
Principal Investigator: Joyce A. O'Shaughnessy, M.D., MB, DCT, NCI 
Study Chairmen: Kenneth H. Cowan, M.D., Ph.D., MB, DCT, NCI 
Arthur W. Nienhuis, M.D., St. Jude Children’s Research Hospital 
Associate Investigators: Kevin T. McDonagh, M.D., CHB, NHLBI 
Brian P. Sorrentino, M.D., CHB, NHLBI 
Cynthia E. Dunbar, M.D., CHB, NHLBI 
Yawen Chiang, Ph.D., Genetic Therapy, Inc. 
Wyndham Wilson, M.D., Ph.D., MB, DCT, NCI 
Anthony Tolcher, M.D., MB, DCT 
Barry Goldspiel, Pharm. D., CC, NIH 
David Kohler, Pharm.D., CC, NIH 
Robert Moen, M.D., Ph.D., Genetic Therapy, Inc. 
Michele Fox, M.D., DTM, NIH 
Susan Leitman, M.D., DTM, NIH 
Michael Gottesman, M.D., LCB, DCBDC, NCI 
Ira Pastan, M.D., LMB, DCBDC, NCI 
Andrea Denicoff, R.N., MB, DCT, NCI 
Marianne Noone, R.N., MB, DCT, NCI 
Ronald Gress, M.D., MB, DCT, NCI 
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