CNS 18 - 4 
ELIGIBILITY CHECKLIST 
Yes No 
>3 years and < 21 years 
_ _ RECURRENT PRIMARY MALIGNANT SUPRATENTORIAL 
GADOLINIUM ENHANCING BRAIN TUMOR without spinal tumor or 
positive CSF cytology. 
J>3 Months after completion CNS irradiation 
Histologic diagnosis previously established 
Refractory to conventional treatment 
Measurable supratentorial tumor accessible for multiple stereotactic 
cannula insertions 
Serum Creatinine <2 x N or creatinine clearance >_80 ml/ min/ m 2 
Coagulation profile within normal range 
Absence of any acute viral, bacterial or fungal infection requiring specific 
therapy 
HIV Negative 
Not pregnant if applicable 
Platelet count > 100,000/mm 3 and absolute neutrophil count _>l,000/mm 3 
Grade III/IV major organ dysfunction due to prior therapy absent. 
Kamofsky score >40 
Life expectancy >2 months 
Informed Consent Obtained 
All answers to above questions must be YES 
Increased intracranial pressure is present. 
Tumor is in direct contact with ventricular or cisternal spaces 
All answers to the above questions must no NO 
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