CNS 18 - 15 
6.0 REQUIRED STUDIES 
Pre-Surgical 
Stereotactic 
surgery 
Ganciclovir 
Therapy 
Mo 1-2 
Mo 3-15 
Height, weight 
X 
Pre 
q 3 mo 
Kamofsky 
X 
Pre, post 
Pre, end 
q 3 mo 
Physical exam 
X 
Pre, post 
Pre, end 
q2 wk 
Neurologic 
evaluation 
X 
Daily 
Daily 
q2 wk 
q mo 
MRI brain 
(DEMRI and 
static Gd contrast) 
X 
within 48 hr 
post-op 
Pre & day 
14 
q mo 
q 3 mo 
‘proton MRS, 
brain 
X 
Day 14 
q mo 
q 3 mo 
Phosphorus MRS, 
brain 
X 
Pre & day 
14 
q mo 
q 3 mo 
MRI spine, 
contrast 
X 
CSF - cells, 
protein, glucose 
X” 
End 
After 1 
mo 
CBC, differential, 
platelet 
X 
2-3 x wk 
q2 wk 
q 3 mo 
Urinalysis 
X 
BUN, creatinine 
X 
2-3 x/wk 
Creatinine 
clearance 
X 
Bilirubin, TP, 
aluminum, GOT, 
GPT, alkaline 
phos 
X 
Weekly 
Coagulation 
profile 
X 
Electrolytes 
X 
Ca, P, uric acid 
X 
Anticonvulsant 
levels 
X (if used) 
Pre 
This study will be performed as part of MRI brain evaluation, above, and will not require separate 
examination or sedation. 
If clinically safe based on patients examination, MRI and in the absence of papilledema. 
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