HUMAN GENE THERAPY PROTOCOL 
RIBOZYME GENE THERAPY FOR HIV-1 INFECTION 
A PHASE 1 CLINICAL TRIAL TO EVALUATE THE SAFETY AND EFFECTS 
IN HIV-1 INFECTED HUMANS OF AUTOLOGOUS LYMPHOCYTES 
TRANSDUCED WITH A RIBOZYME THAT CLEAVES HIV-1 RNA 
Principal Investigator: Flossie Wong-Staal, Ph.D. 
Co-Principal Investigators: Eric Poeschla, M.D. 
David Looney, M.D. 
Investigators: Mang Yu, Ph.D. 
Mark Leavitt, Ph.D. 
Osamu Yamada, Ph.D. 
Jiing-Kuan Yee, Ph.D. 
University of California - San Diego 
Submitted to the Recombinant DNA Advisory Committee on July 14, 1 993 
[380] 
Recombinant DNA Research, Volume 18 
