TABLE OF CONTENTS 
PAGE 
PROTOCOL ROSTER 4 
PROTOCOL SYNOPSIS 5 
SCHEMATIC 6 
ABSTRACT 7 
1.0 BACKGROUND AND RATIONALE 8 
2.0 STUDY DESIGN 8 
3.0 STUDY TREATMENT 9 
3.1 Preparation of Autologous Tumor 9 
3.2 Human IL-2 Producing M24 10 
3.3 Vaccine Preparation 10 
3.4 Vaccine Administration 11 
4.0 PATIENT SELECTION 11 
4.1 Inclusion Criteria 11 
4.2 Exclusion Criteria 12 
4.3 Concomitant Medication and Treatment 12 
4.4 Medications and Treatments Not Allowed 12 
5.0 CLINICAL AND LABORATORY EVALUATIONS 13 
5.1 Screening and Baseline Evaluations 13 
5.2 Interval Evaluations 14 
5.3 Post-Treatment Evaluations 
(see Appendix I) 
6.0 TREATMENT MODIFICATION AND DISCONTINUATION 
ACCORDING TO LEVEL OF TOXICITY 14 
6.1 Treatment Modification and General Management of Toxicides 15 
) 
6.2 Symptomatic Therapy for Toxicity 15 
(see Appendix II) 
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