^rccai rvesrgatcr P'ogram Director last -node’ 
BIOGRAPHICAL SKETCH 
Give the following information for the Key personnel and consultants and collaborators Begin with the principal 
investigator/program director. Photocopy this page for each person 
J POSITION TITLE 
James S. Economou, M.D., Associate Professor of Surgery 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training ) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
The Johns Hopkins University 
B. A. 
1972 
Biology 
The Johns Hopkins University 
M.D. 
1980 
Medicine 
School of Medicine 
Ph.D. 
1980 
Immunology 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience 
honors. Key personnel include the principal investigator and any other individuals who participate m the scientific development or execution of tne orciect 
Key personnel typically will include all individuals with doctoral or other professional degrees, but m some proiects will include individuals at the masters or 
baccalaureate level provided they contnbute in a substantive way to the scientific development or execution of the proiect. Include present memoersn,o on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications du^g ,r -e 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
1980-1986 Residency in General Surgery UCLA, UCSF 
1986-1990 Assistant Professor of Surgery UCLA 
1990-present Associate Professor of Surgery UCLA 
Economou JS, Essner R, Rhoades K, McBride WH, Golub S, Holmes EC, Morton DL. Molecular 
mechanisms of interleukin-2 (IL-2) induction of human necrosis factor (TNE) gene 
expression in macrophages. Surgical Forum 39:426-428, 1988. 
onomou JS, Colquohoun SD, Anderson TM, McBride WH, Golub S, Holmes, E.C., Morton, O.L. 
interleukin-1 and tumor necrosis factor production by tumor-associated mononuclear 
leukocytes and peripheral mononuclear leukocytes in cancer patients. International 
Journal of Cancer 42:712-714, 1988. 
Economou JS, McBride WH, Essner R, Rhoades KR, Golub S, Holmes EC, Morton DL. Tumor 
necrosis factor production by interleukin-2 activated macrophages in vitro , and m vivo . 
Immunology, 67:514-519-1989. 
Essner R, Rhoades K, McBride WH, Morton DL, Economou JS. IL-4 downregulates IL-1 and TNF 
gene expression in human monocytes. J of immunology 142:3857-3861, 1989. 
Economou JS, Rhoades K, Essner R, McBride WH, Gasson JC, Morton DL. Genetic analysis of 
the human tumor necrosis factoro/cachectin promoter region in a macrophage cell line. 
Journal of Experimental Medicine, 170:321-326, 1989. 
Economou JS, Essner R, Rhoades K, Yamada T, Swisher S, Holmes EC, Golub S, Morton, DL. 
Genetic analysis of tumor necrosis factor promoter function in human tumor-infiltrating 
lymphocytes and other cell lines. Surgical Forum 40:448-452, 1989. 
Golub SH, Iho S, Gallardo D, Ebina N, Swisher SG, Economou JS, Shau H. Cytokine 
regulation of the induction of cytotoxic effector cells by IL-2 in Proceedings of the 6th 
International NK. Workshop. R.E. Schmidt (ed), Karger, Basel, 1989. 
wisher SG, Economou JS, Holmes EC, Golub SH. TNF -a and IFN-y reverse IL-4 inhibition of 
mphokine-activated killer cell function. Cellular Immunology, 128:450-461, 1990 
McBride, W.H., Economou, J.S. ,Nayersina,R. ,Comora,S. , Essner, R. The influence of IL-2 and 
IL-4 on TNF production by mononuclear phagocytes. Cancer Research, 50:2949-2952, l^u. 
PHS 398 (Rev. 9/91) ~ (Form Page 6) Page 
Number pages consecutivety at the bottom throughout the appftcaSon. Do not um suffixes such as 3a. 3b. [4391 
Recombinant DNA Research, Volume 18 
