* * * TABLE OF CONTENTS * * * 
I. Call to Order 6 
II. Minutes of the September 9-10, 1993, RAC Meeting 6 
III. Chair Report on Minor Modifications to NIH-Approved Human Gene 
Transfer Protocols/Dr. Walters 7 
IV. Working Group on Data Management - Semi-Annual Data Report 
/Dr. Leventhal 7 
V. Update of the Oldfield Protocol Entitled: Gene Therapy for the 
Treatment of Brain Tumors Using Intra-Tumoral Transduction with the 
Thymidine Kinase Gene and Intravenous Ganciclovir (#9206-0 19)/Dr. Ram .... 8 
VI. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Intrathecal Gene Therapy for 
the Treatment of Leptomeningeal Carcinomatosis /Drs. Oldfield and Ram 9 
VII. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene 
Transfer Protocol Entitled: Retroviral Mediated Gene Transfer of 
the Fanconi Anemia Complementation Group C Gene to Hematopoietic 
Progenitors of Group C Patients /D rs. Liu and Young 11 
VIII. Continuation of Discussion Regarding a Human Gene Transfer Protocol 
Entitled: A Phase I Clinical Trial to Evaluate the Safety and 
Effects in HIV-1 Infected Humans of Autologous Lymphocytes Transduced 
with a Ribozyme that Cleaves HIV-1 RNA /Dr. Wong-Staal (see previous 
discussion under Call to Order) 17 
IX. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Therapy Protocol Entitled: Injection of Colon Carcinoma 
Patients with Autologous Irradiated Tumor Cells and Fibroblasts 
Genetically Modified to Secrete Interleukin-2 /Drs. Sobol and Royston 17 
X. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Transfer Protocol Entitled: Injection of Glioblastoma 
Patients with Tumor Cells Genetically Modified to Secrete 
Interleukin-2 (IL-2): A Phase I Study/ Drs. Sobol and Royston 20 
XI. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Therapy Protocol Entitled: Retrovirus-Mediated Transfer 
of the cDNA for Human Glucocerebrosidase into Peripheral Blood 
Repopulating Cells of Patients with Gaucher's Disease /Dr. Schuening 23 
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Recombinant DNA Research, Volume 18 
