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(M) Brenner, Malcolm K.; Krance, Robert; Heslop, Helen E.; Santana, Victor, and Ihle, James, St. Jude Children’s Research 
Hospital, Memphis, Tennessee; Assessment of the Efficacy of Purging by Using Gene-Marked Autologous Marrow Transplantation 
for Children with Acute Myelogenous Leukemia in First Complete Remission. 
RAC Approval: 3-2-93/NIH Approval: 4-16-93 
(T) Simons. Jonathan. Johns Hopkins Oncology Center. Baltimore. Maryland: Phase I Study of Non-Replicating Autologous Tumor 
Cell Injections Using Cells Prepared With or Without Granulocyte-Macrophage Colony Stimulating Factor Gene Transduction in 
Patients with Metastatic Renal Cell Carcinoma. 
RAC Approval: 3-1-93 
(T) Wilmott, Robert W. and Whitsett, Jeffrey, Children’s Hospital Medical Center, Cincinnati, Ohio, and Trapnell, Bruce; Genetic 
Therapy, Inc., Gaithersburg, Maryland; A Phase I Study of Gene Therapy of Cystic Fibrosis Utilizing a Replication Deficient 
Recombinant Adenovirus Vector to Deliver the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA to the 
Airways. 
RAC Approval: 3-2-93/NIH Approval: 4-16-93 
(T) Boucher, Richard C and Knowles, Michael R., University of North Carolina, Chapel Hill, North Carolina; Gene Therapy for 
Cystic Fibrosis Using El Deleted Adenovirus: A Phase I Trial in the Nasal Cavity. 
RAC Approval: 3-2-93/NIH Approval: 10-7-93 
(T) Seigler, Hilliard F., Duke University Medical Center, Durham, North Carolina; A Phase I Trial of Human Gamma Interferon- 
Transduced Autologous Tumor Cells in Patients With Disseminated Malignant Melanoma. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Deisseroth. Albert B.: Kavanagh. John: and Champlin. Richard, University of Texas MD Anderson Cancer Center. Houston. 
Texas: Use of Safety-Modified Retroviruses to Introduce Chemotherapy Resistance Sequences into Normal Hematopoietic Cells for 
Chemoprotection Purine the Therapy of Ovarian Cancer: A Pilot Trial. 
RAC Approval: 6-7-93 
(T) Nabel, Gary J., University of Michigan Medical Center, Ann Arbor, Michigan; Immunotherapy for Cancer by Direct Gene 
Transfer into Tumors. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Barranger, John A., University of Pittsburgh, Pittsburgh, Pennsylvania, Gene Therapy for Gaucher Disease: Ex Vivo Gene 
Transfer and Autologous Transplantation of CD34(+) Cells. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Kartsson, Stefan and Dunbar, Cynthia, National Institutes of Health, Bethesda, Maryland, and Kohn, Donald B., Childrens 
Hospital Los Angeles, Los Angeles, California; Retroviral Mediated Transfer of the cDNA for Human Glucocerebrosidase into 
Hematopoietic Stem Cells of Patients with Gaucher Disease. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Galpin, Jeffrey E., University of Southern California, and Casciato, Dennis A., University of California, Los Angeles, 
California; A Preliminary Study to Evaluate the Safety and Biologic Effects of Murine Retroviral Vector Encoding HIV-1 Genes 
[HIV -IT '(V)] in Asymptomatic Subjects Infected with HIV-1. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Nabel, Gary J., University of Michigan Medical Center, Ann Arbor, Michigan; A Molecular Genetic Intervention for AIDS - 
Effects of a Transdominant Negative Form of Rev. 
RAC Approval: 6-7-93/NIH Approval: 9-3-93 
(T) Sobol, Robert and Royston, Ivor, San Diego Regional Cancer Center, San Diego, California; CONFIDENTIAL. 
NIH Approval: 12-28-92 
Major Amendment (Expedited Review)/NIH Approval: 5-11-93 
(T) Raffel, Corey, Childrens Hospital Los Angeles, Lo6 Angeles, California, and Culver, Kenneth, Iowa Methodist Medical Center, 
Des Moines, Iowa; Gene Therapy for the Treatment of Recurrent Pediatric Malignant Astrocytomas with In Vivo Tumor 
Transduction with the Herpes Simplex Thymidine Kinase Gene. 
RAC Approval: 6-8-93/NIH Approval: 9-3-93 
(T) Hesdorffer, Charles and Antman, Karen, Columbia University College of Physicians and Surgeons, New York, New York; 
Human MDR Gene Transfer in Patients with Advanced Cancer. 
RAC Approval: 6-8-93/NIH Approval: 9-3-93 
fT) Ilan. Joseph. Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland. Ohio; 
Gene Therapy for Human Brain Tumors Using Episome-Based Antisense cDNA Transcription of Insulin-Uke Growth Factor I. 
RAC Approval: 6-8-93 
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Recombinant DNA Research, Volume 18 
