9309-053 
9309-054 
9309-055 
9309-056 
9309-057 
9309-058 
Attachment II - Page 5 
(T) Cassileth, Peter; Podack, Eckhard R.: Sridhar. Kasi: University of Miami, and Savarai. Niramol: Miami Veterans 
Administration Hospital. Miami. Florida; Phase I Study of Transfected Cancer Cells Expressing the Interleukin-2 Gene Product in 
Limited Stage Small Cell Lung Cancer. 
RAC Approval: 9-9-93 
(T) O’Shaughnessy, Joyce; National Institutes of Health, Bethesda, Maryland; Retroviral Mediated Transfer of the Human Multi-Drug 
Resistance Gene (MDR-1) into Hematopoietic Stem Cells During Autologous Transplantation after Intensive Chemotherapy for 
Breast Cancer. 
RAC Approval: 9-9-93 
(T) Run, Larry E.; Sanford, R. A.; Brenner, Malcolm K.; and Heideman, Richard L.; St. Jude Childrens Research Hospital, 
Memphis, Tennessee; and Oldfield, Edward H.; National Institutes of Health, Bethesda, Maryland; Gene Therapy for Recurrent 
Pediatric Brain Tumors. 
RAC Approval: 9-9-93 
(T) Das Gupta. Tapas K. and Cohen. Edward P.: University of Illinois at Chicago: Chicago. Illinois: Immunization of Malignant 
Melanoma Patients with Interleukin 2-Secreting Melanoma Cells Expressing Defined Allogeneic Histocompatibility Antigens. 
RAC Approval: 9-10-93 
(T) Wong-Staal. Flossie: Poeschla. Eric: and Looney, David: University of California. San Piero. California: A Phase I Clinical 
Trial to Evaluate the Safety and Effects in HTV-1 Infected Humans of Autologous Lymphocytes Transduced with a Ribozvme that 
Cleaves HIV-1 RNA. 
RAC Approval: 9-10-93 
(T) Economou. James S. and Glasbv, John A.: University of California Medical Center. Los Angeles. California: Genetically 
Engineered Autologous Tumor Vaccines Producing Interleukin-2 for the Treatment of Metastatic Melanoma. 
RAC Approval: 9-10-93 
T 
M 
Total (T + M) 
RAC APPROVED 
35 
23 
58° 
NIH DIRECTOR APPROVED 
28 
22 
50 
LEGEND: 
M = Human Gene Marking Protocol 
T = Human Gene Therapy Protocol 
* = Minor Modification^) 
b = Major Amendment(s) 
c = The number of protocols appearing in the table is greater than the number that appears in the protocol list because of the single Expedited Review 
protocol that was approved by the NIH Director on 12-28-92. 
_ = RAC Approved/NIH Approval Pending 
JaiMmiy 31, 1994 
I 
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