Status 
(Open/ 
Closed) 
Open 
Oh 
P/FDA 
Closed 
Closed 
P/FDA 
P/FDA 
and NIH 
P/FDA 
and NIH 
P/FDA 
Open 
Open 
# 
Deaths 
- 
Ok 
a* 
CU 
Oh 
Oh 
Oh 
o. 
Oh 
o 
o 
Adverse 
Effects 
No 
Cu 
0- 
Oh 
Oh 
Oh 
Oh 
Oh 
Oh 
Oh 
Yes 
(trans- 
ient, 
mild, 
inflam- 
mation) 
Problems 
with Gene 
Transfer 
No 
Oh 
Oh 
Oh 
Oh 
Oh 
Oh 
Oh 
Oh 
Oh ; 
No 
In Vivo 
Evidence 
of Gene 
Transfer 
(Human) 
Yes 
Ok 
Ck 
Oh 
Oh 
0h 
Oh 
Oh 
Oh 
CU 
Yes 
Patient 
Accrual 
To 
Date 
»/*> 
o 
o 
O 
O 
O 
© 
o 
o 
- 
Maximum 
Patient 
Accrual 
C4 
cq 
<N 
8 
8 
8 
o 
■*r 
8 
Vector 
Supplier 
GTI 
LLO 
LLO 
TGC 
TGC 
TGC 
GTI 
GTI 
LLO 
LLO 
Cornell 
Packag- 
ing Cell 
PA317 
PA317 
PA317 
PA317 
PA317 
PA317 
PA317 
GP + cnv 
AM12 
PA317 
PA317 
293 
Vector/ 
Gene 
X ct 
8 8 
3 3 
si Bi 
8 8 
3 "z 
3 3 
X of 
8 8 
|"z 
3 3 
* 
8 
c 
3 
si 
8 
c 
3 
k 
8 
c 
3 
Si o£ 
o o 
V O 
Z T> Z 
I s ! 
3 5 
LNSX-AS-K- 
ras and 
LNSX-p53 
* a 
8 8 
z 
a o 
GlIIASvNa 
□ ^ 
Date 
First 
Patient 
Treated 
s 
§ 
Oh 
CU 
cu 
Oh 
Oh 
Oh 
Oh 
CU 
? 
O' 
4-17-93 
Patients 
BMM/ 
Breast 
Cancer 
BMM/ 
CML 
HIV+/ 
Identical 
Twin 
BMM/ 
Breast 
Hodgkin's 
Disease 
BMM/ 
Lymphoid 
Malig. 
BMM/ 
Identical 
Twins 
BMM/ 
CLL 
Cancer/ 
NSCLC 
BMM/ 
NBL 
Cancer 
CF 
M/T 
2 
2 
2 
2 
2 
2 
2 
H 
2 
H 
t 
a Is 
Z |a 
< 
8-14-92 
8-14-92 
9-3-93 
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§ 
$ 
2-5-93 
Oh 
Oh 
2-5-93 
2-5-93 
4-16-93 
U 1 a 
s|.f 
I 
6-2-92 
9-14-92 
9-14-92 
9-14-92 
9-14-92 
9-14-92 
9-15-92 
9-15-92 
9-15-92 
Is 
£ 
1 ^ 
Institution 
NIH 
NIH 
HIN 
Fred 
Hutchinson 
Fred 
Hutchinson 
Fred 
Hutchinson 
MD 
Anderson 
MD 
Anderson 
St. Jude 
U. of 
Pittsburgh 
| Cornell 
3 
E 
Dunbar 
Dunbar 
Walker 
Schuening 
Schuening 
Schuening 
Deisseroth 
Roth 
Brenner 
Lotze 
a 
h 
u 
<ik 
9206-024 
1 
1 
9209-027 
9209-028 
9209-029 
9209-030 
9209-031 
9209-032 
9209-033 
9212-034 8 
[584] 
Recombinant DNA Research, Volume 18 
