3.0 Treatment And Monitoring Schema (Revised) 
The ideal treatment and monitoring schedules are summarized in Figures 5 and 6. After 
each injection, patients will be contacted daily for 3 days to determine if the injection site 
is swollen or red. If a history of any erythema or induration is elicited, then the patient 
will be examined within 24 hours. All subjects will be examined 14 days after each 
immunization. Physical examinations and laboratory evaluations will be performed every 
two weeks during the first 8 weeks of the study, once a month for three months and every 
3 months for one year after the completion of therapy and at least yearly thereafter. 
Figure 5 Treatment and Monitoring Summary 
Day - 60 
Skin biopsies 
Genetic modification of fibroblasts 
Days + 0,14,28 
Immunization with irradiated transduced 
tumor cells 
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