Non-technical Abstract 
Non-Technical Abstract 
Many types of cancer cannot be cured by traditional medical treatments, 
including drugs, surgery, or radiation. In this study, an experimental treatment will be 
offered that may help to fight this disease. We will attempt to induce tumor regression 
by the introduction of genetic material that directs the synthesis of proteins which 
stimulate the immune system. The genetic material, DNA, will be introduced directly 
into the tumor by mixing it with fatty substances, or lipids, and this mixture will be 
injected into the tumor. The DNA will be taken into cells and cause them to produce 
proteins that stimulates tissue rejection. These proteins, called histocompatibility 
proteins, cause cells which contain it to be recognized as foreign by the immune 
system. The goal of the treatment is to stimulate the immune system to attack and kill 
the tumor. In this study, we will attempt to determine the optimal safe and effective 
dose to administer the DNA/lipid complex. Increasing amounts of this complex will 
be used in different patient populations. If no side effects are observed, repeated 
treatments will be instituted. The expression and nature of the immune response will 
also be characterized. This treatment may provide a therapeutic effect in cancer and 
could be applied to the treatment of other diseases. 
Recombinant DNA Research, Volume 18 
[751] 
