Principal Investigator/Program Director (Last, first, middle): Sorscher, Eric. J. 
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BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
name 
POSITION TITLE 
JAMES J. LOGAN 
-Em irAT ION IReain with baccalaureate or other initial profes 
Assistant Professor of Pediatrics 
sional education, such as nursina. and include postdoctoral trainina.l 
m 
YEAR 
INSTITUTION AND LOCATION 
DEGREE 
CONFERRED 
FIELD OF STUDY 
Clark University, Worchester, MA 
University of North Carolina at Chapel Hill, NC 
B.A. 
M.D. 
1975 
1984 
Chemistry 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors. 
Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. Key 
heij personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
" 1 baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
10 Cj 
1980-1985 Graduate studies in Organic Chemistry, Duke University 
Complete all requirements for Ph.D. except dissertation 
1985-1987 Pediatric Residency, University of Alabama at Birmingham 
Birmingham, Alabama 
; 1990 Pediatric Flexible Bronchoscopy Course 
Chapel Hill, North Carolina 
1990-1993 Fellowship, Pediatric Pulmonology 
University of Alabama at Birmingham 
1993- Assistant Professor of Pediatrics, The Children's Hospital of Alabama, 
present Birmingham, AL 
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in: f 
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PUBLICATIONS AND ABSTRACTS 
Logan, J., Porter, N. and Kontoyiannidou, V. Preparation of arachidonic acid hydroperoxides of biological importance, J. 
Organic Chem. 44:31 77, 1979. 
Logan, J„ Huang, Z., Muccio, D., Hartland, J., Peng, S. and Sorscher, E. Purification and characterization of the first 
nucleotide binding domain of CFTR. Ped. Pulm. Suppl. 8:262,1992. 
Peng, S., Sommerfelt, M., Logan, J., Huang, Z., Jilling, T. ( Kirk, K., Hunter, E., and Sorscher, E. One step affinity 
purification of recombinant protein using the baculovirus/insect cell expression system, Protein Expression and Purification, 
4/2:95-1 00, 1993. 
Peng, S., Jilling, T., Sommerfelt, M., Huang, Z., Logan, J., Kirk, K., Hunter, E., and Sorscher, E. Single step affinity 
purification of CFTR polypeptides using the baculovirus expression system. Ped. Pulm. Suppl. 8:213,1992. 
Sorscher, E.J., P. Daram, D. Hiestand, Z. Huang, S. Peng, D. Muccio, B. Haley and J. Logan. Mutations in CFTR nucleotide 
binding domains (NBD's) disrupt trinitrophenyl ATP binding. FASEB J., 7:A426, 1993. 
Logan, J., D. Hiestand, Z. Huang, D. Muccio, B. Haley, and E. J. Sorscher. 3-isobutyl-1 -methylxanthine (IBMX) blocks 
binding of ATP analogs to the CFTR first nucleotide binding domain (NBD-1 ). FASEB J., 7:A426, 1 993. 
Logan, 
dfA a Se a s n e^. u « D eM 
uccio, B. Haley, W. J. Cook, and E.J. Sorscher. 
[fiST 
Mutations 
