M.J. Welsh and A.E. Smith, RAC Application 
APPLICATION TO 
NATIONAL INSTITUTES OF HEALTH 
RECOMBINANT DNA ADVISORY COMMITTEE 
TITLE 
ADENOVIRUS-MEDIATED TRANSFER OF CFTR TO THE NASAL EPITHELIUM AND 
MAXILLARY SINUS OF PATIENTS WITH CYSTIC FIBROSIS 
INVESTIGATOR 
Michael J. Welsh, M.D. 
Howard Hughes Medical Institute 
Departments of Internal Medicine and Physiology and 
Biophysics 
University of Iowa College of Medicine 
Iowa City, Iowa 52242 
CQINy ESTIG ATORS . 
UNIV. OF IOWA 
Joseph Zabner, M.D. 
Department of Internal Medicine 
Scott M. Graham, M.D. 
Department of Otolaryngology 
SPONSOR, 
Genzyme Corporation 
One Kendall Square 
Cambridge, M A 02139 
SPONSOR'S RESPONSIBLE 
SCIENTISTS 
Alan E. Smith, Ph.D. 
Sr. Vice President, Research 
Samuel C. Wadsworth, Ph.D. 
Molecular Biology 
Bruce M. Pratt, Ph.D. 
Cell Physiology 
Richard A. Moscicki, M.D. 
Medical and Regulatory Affairs 
[860] 
Recombinant DNA Research, Volume 18 
