M.J. Welsh and A.E. Smith, RAC Application 
Ad2-ORF6/PGK-CFTR 
Table of Contents 
Table of Contents 
1.0 Scientific Abstract 
2.0 Non-technical Abstract 
3.0 IBC and IRB Approvals 
4.0 Points to Consider 
5.0 Protocol 
6.0 Approved Informed Consent Documents 
7.0 Appendices 
7.1 Structure and Characteristics of the Biological System 
7.2 Preparation, Structure and Composition of Clinical Material 
7.3 Laboratory Studies of Delivery System 
7.4 Laboratory Studies of Gene Transfer, Expression, and Safety of the 
Delivery System 
7.5 Manuscript: Development and Analysis of Recombinant Adenoviruses for 
Gene Therapy of Cystic Fibrosis , Rich, et al. (1993). 
7.6 Manuscript: Safety and Efficacy of Repetitive Adenovirus-Mediated Transfer 
ofCFTR cDNA to Airway Epithelia of Primates and Cotton Rats , Zabner, et 
al. (1993). 
7.7 Manuscript: Efficiency of Adenovirus-Mediated Transfer of CFTR at 
Correcting cAMP-Stimulated Fluid Secretion and Chloride Transport in 
Cystic Fibrosis Airway Epithelia In Vitro , Zabner, et al. (submitted for 
publication). 
7.8 Manuscript: Adenovirus-Mediated Gene Transfer Transiently Corrects the 
Chloride Transport Defect in Nasal Epithelia of Patients With Cystic 
Fibrosis, Zabner, et al. (submitted for publication) 
8.0 Curricula Vitae 
Recombinant DNA Research, Volume 18 
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