M.J. Welsh and A.E. Smith, RAC Application 
Ad2-ORF6/PGK-CFTR 
Item 8 - Professional Experience 
of Key Personnel 
FF Principal Investigator/Program Director (Last, first, middle): M.J. Welsh and A.E. Smith 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME 
POSITION TITLE 
Welsh, Michael J. 
Professor 
EDUCATION (Begin with baccalaureate of other initial professional education, such as nursing, and indude postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Loras College, Dubuque, Iowa 
1967-69 
Liberal Arts 
University of Iowa, Iowa City, Iowa 
B.S. 
1970 
Gen. Science 
University of Iowa College of Medicine 
M.D. 
1974 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, 
experience, and honors. Key personnel include the principal investigator and any other individuals who participate in the scientific 
development or execution of the project. Key personnel typically will include all individuals with doctoral or other professional degrees, 
but in some projects will include individuals at the masters or baccalaureate level provided they contribute in a substantive way to the 
scientific development or execution of the project. Include present membership on any Federal government public advisory committee. 
List, in chronological order, the titles, all authors, and complete references to all publications during the past three years and to 
representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
Year 
Position 
Institution 
7/74 - 6/77 
Intern and Resident 
Internal Medicine, University of Iowa, Iowa City, IA 
7/77 - 679 
Research Fellowship 
Cardiovascular Research Institute, University of 
California at San Francisco, San Francisco, CA 
7/79- 12/80 
Research Fellow 
Department of Physiology, Univ. of Texas 
Medical School at Houston, TX 
1/81 - 6/84 
Assistant Professor 
Pulmonary Division, Department of Internal 
7/84 - 6/87 
Associate Professor 
Medicine, University of Iowa College of Medicine 
7/87 - present 
Professor 
Iowa City, IA 
1989 - 
Professor 
Physiology and Biophysics, University of Iowa 
College of Medicine, Iowa City, IA 
1989 - 
Investigator 
Howard Hughes Medical Institute 
Year 
Honor 
1977 Cecile Lehman Mayer Research Award, American College of Chest Physicians 
1977 National Pulmonary Faculty Training Award 
1983 Established Investigator of the American Heart Association 
1983 American Society for Clinical Investigation 
1989 American Association of Physicians 
1992 Doris F. Tulcin Cystic Fibrosis Research Award 
Bibliography — Papers Published or In Press 
Welsh. MJ. Acidification Indication. Nature 352 :23-24. 1991. 
Anderson MP, Rich DP, Gregory RJ, Smith AE, and Welsh MJ. Generation of cAMP-Activaied Chloride 
Currents by Expression of CFTR. Science 251 :679-682. 1991. 
Anderson MP, and Welsh, MJ. Calcium and cAMP Activate Different Chloride Channels in the Apical 
Membrane of Normal and Cystic Fibrosis Epithelia. Proc. Natl Acad. Sci. U.S.A. 88:6003-6007. 1991. 
Denning GM, and Welsh MJ. Polarized Distribution of Bradykinin Receptors on Airway Epithelial Cells 
and Independent Coupling to Second Messenger Pathways. J. Biol. Chem. 266 :12932-12938. 1991. 
Gregory RJ, Rich DP, Cheng SH, Souza DW, Paul S, Manavalan P, Anderson MP, Welsh MJ, and Smith AE. 
Maturation and Function of CFTR Variants Bearing Mutations in Putative Nucleotide Binding Domains 1 
& 2. Mol. Cell. Biol. 11:3886-3893, 1991. 
Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, and Welsh MJ. 
Demonstration that CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity. Science, 253 :202- 
205, 1991. 
Rich DP, Gregory RJ, Anderson MP, Manavalan P, Smith AE, and Welsh MJ. Effect of Deleting the R 
Domain on CFTR-Generated Chloride Channels. Science 253:205-207. 1991. 
PHS 398 (Rev. 9/91) (Form Page 6) Page 
Number pages consecutively at the bottom throughout the application. Do not use suffices such as 3a, 3b. 
[896] 
Recombinant DNA Research, Volume 18 
