12 
Dr. Gottesmn suggested the preantole of part III of the working group document 
might include language indicating that information to better evaluate the 
probability of survival, establishment, dispersal, etc., would be most important 
in evaluating a proposal. Dr. Carl Mazza of the EPA suggested language emphasizing 
the importance of comparing the modified organism to the parental organism might 
be included in this preamble. 
Dr. Colwell and working group members developed the following list of pertinent 
considerations : 
A. Natural Habitat 
B. Ihysical and Chemical Factors Influencing Survival and Growth 
C. Biological Interactions 
1. Host Range 
2. Predators 
3. Competitors 
4. Mutualistic Interactions 
D. Evolutionary Considerations, Rate /Likelihood 
E. Movement of Genetic Information to Other Organisms 
Dr. Gottesmn asked the working group vhat types of information on experimental 
design should be requested of the submitter in part IV of the document. She 
suggested this part of the document should request information on greenhouse 
testing and monitoring methods. She noted that page four of the subgroup 
preliminary draft document (Attachment IV) contained informational requirements 
for experimental conditions, control experiments and monitoring, and asked 
if these points were adequately addressed by this document. 
Dr. Colwell suggested the working group document should request information about 
target organisms. Dr. Tolin suggested the language on page five of the original 
subgroup draft (Attachment IV) requests information on target organisms and might 
be useful in constructing the working group document. Dr. Colwell felt infor- 
mational requests on ecologically and genetically related organisms should be 
emphasized. Dr. Pi rone agreed; he thought the language of the working group 
document should emphasize requests for information on closely related organisms 
found near the test site. 
Dr. Tolin said Part IV of the working document should ask the investigator to 
explain why problems will not arise with the field test and to justify why the 
field trial should be permitted. 
Dr. Gottesnan then composed the following outline for that section of part IV 
dealing with infornation requirements for experimental conditions: 
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