19 
Dr. Colwell thought the following points involving effects on other nontarget 
organisms should be taken fran the EPA document (Attachment VIII) and added to 
part III of the Gottesman document (Attachment XI): 
"o Pathogenicity, infectivity (acute or chronic), toxicity, virulence, 
colonization, or pathogen vector in animals, plants, or microorgani sms ; 
"o Antigenicity to animals? and 
"o Host range." 
Dr. Colwell suggested the following points on ecosystem effects be taken frcm 
the EPA document (Attachment VIII): 
"o Mature of any antibiotic resistance; potential use of these antibiotics 
in humans and domestic organisms? 
"o Potential or known involvement in biogeochemical processes (e.g., 
mineral cycling, cellulose and lignin degradation, nitrogen fixation); 
"o Potential or known effects on population levels of other organisms 
in the environment, including effects on competitors, prey, hosts, 
symbionts, predators, parasites, pathogens? 
"o Other effects on habitats, such as effects on species diversity; 
"o Ability to form survival structures (e.g., spores, sclerotia); 
"o Potential biological ly-active metabolites resulting from the action 
of the genetically-engineered organism or its product? 
"o Other potentially significant physiological or ecological traits? and 
"o Stability of these traits." 
Dr. Gottesman suggested the point referring to antigenicity not be introduced 
into the Gottesman document (Attachment XI) as most biological substances are 
antigenic. She suggested the Gottesman document (Attachment XI) refer simply 
to "effects on other organisms." 
Dr. Tolin suggested investigators should be asked to document kno*/n effects on 
biogeochemical processes. Dr. Miller suggested language requesting predicted 
effects on biogeochemical processes should also be included in tire document. 
Dr. Colwell agreed to add such language to the document. 
Dr. Tolin suggested language requesting data on the likelihood of exchange of 
genetic information between the modified organism and other organisms in nature 
should be included in this portion of the Gottesman document. 
Dr. Gottesman called the attention of the working group to part IV of the docu- 
ment. She said part IV of the Gottesman document is based primarily on the 
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