5 
I. CALL to order and opening remarks 
Mr. Mitchell, Chair, called the meeting of the Reccmbinant ENA Advisory 
Committee (RAC) to order. He noted that 22 members of the 25 member 
committee were present and constituted a quorum. Mr. Mitchell said the 
matters the cannittee would consider were published in the Federal Register 
of September 20, 1984, in compliance with requirements for thirty days of 
public notice. 
Mr. Mitchell announced he would recognize individuals in the following 
order: primary reviewers; other RAC members; ad hoc consultants; non-voting 
representatives to RAC; RAC's administrative staff; members of the public 
who submitted written comments; and finally other members of the public 
who wish to comment. 
II. MINUTES OF TOE JUNE 1, 1984, MEETING 
Mr. Mitchell called on Mr. Daloz to review the minutes (tab 1191) of the 
June 1, 1984, RAC meeting. Mr. Daloz said he and Dr. Harvin had reviewed 
the minutes of the June 1, 1984, meeting and found them to be in order. He 
moved that RAC accept the minutes as written. Dr. Harvin seconded the 
motion. 
Dr. McGarrity asked whether the attachments mentioned in the text of the 
minutes would be attached by NIH staff to the final version of the minutes. 
Dr. Gartland said NIH staff would add the attachments to the minutes before 
publication. 
Dr. Walters questioned the use of the word "exotoxinosis" in item VI, 
Proposal to Clone Shiga-Like Toxin Gene from E. coli . Mr. Mitchell asked 
NIH staff to check this word for veracity and accuracy. 
By a unanimous vote the RAC accepted the minutes of the June 1, 1984, meeting. 
III. REPCRT OF TOE WORKING GROUP ON RET EASE INTO THE ENVIRONMENT 
Mr. Mitchell called on Dr. McGarrity, Chair of the RAC Working Group on 
Release into the Environment, to report (tabs 1189, 1190) on the activities 
of that working group. 
Dr. McGarrity said the Working Group on Release into the Environment is 
composed of twelve individuals: eleven biologists with expertise in plant 
biology, molecular biology, and ecology, and one lawyer. The working group 
also has representatives from the U.S. Department of Agriculture (USDA), 
the Food and Drug Administration (FDA), and the Environmental Protection 
Agency (EPA), and ad hoc consultants. 
Dr. McGarrity said the Working Group on Release into the Environment had 
presented to RAC at the June 1, 1984, meeting a "points to consider" 
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