8 
Dr. Lacy suggested the following phrase should be added to this sentence: 
"...that have been modified by recombinant DNA techniques." 
Dr. Arntzen suggested the phrase "open air testing" might be substituted for 
the phrase "release into the environment." Dr. Vidaver replied that the 
environment is the open air. 
Dr. Colwell suggested the title of the working group draft should read: 
"Points to Consider for Submissions Involving Testing and Application of 
Microorganisms Containing Reccmbinant DNA Molecules into the Environment." 
Dr. Colwell noted that the second paragraph of the preamble would then read: 
"These following 'Points to Consider' have been developed by the Working 
Group on Release into the Environment as a suggested list for scientists 
preparing proposals on environmental testing and applications into the 
environment of microorganisms including viruses, that have been modified 
by reccmbinant DNA techniques." 
Dr. Vidaver suggested the third paragraph of the preamble should read as follows 
"The review of proposals for environmental testing of organisms containing 
reccmbinant DNA is being done on a case-by-case basis because the infinite 
range of possible organisms, applications, and environments indicate that 
no single set of tests is likely to be appropriate in all circumstances. 
However, sane common considerations allow the construction of 'Points to 
Consider' such as those below." 
Dr. Lacy suggested the phrase "modified organism" be substituted for the phrase 
"organisms containing reccmbinant DNA." Dr. Segal suggested the word 
"standard" be substituted for the word "single." Dr. Gottesman suggested the 
word "procedures" be substituted for the word "tests." Dr. McGarrity said he 
was uncomfortable with the word "infinite;" he suggested this word be deleted 
from the paragraph. 
Dr. Gottesman thought the preamble should indicate some common considerations. 
These would include the concepts of: (1) hew different the modified organism 
is from the parental organism; and (2) the probable effect of the modified 
organism on the environment. Dr. Clowes supported Dr. Gottesman 's contention 
that these considerations should be mentioned in the preamble to the document. 
Dr. Lacy disagreed; he felt this type of information was implicitly associated 
with risk assessment considerations and thought language dealing with these 
concerns should be in the summary of the document. 
Dr. Sharpies suggestei language referring to the uniqueness issue should be 
deleted from the preamble of the working group draft and the following sentence 
substituted: 
[ 185 ] 
