Attachment IV - Page 1 
ROBERT E. MITCHELL 
attouncy at caw 
• lOU'x SAM ANTONIO OAlVC 
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CNAIMMAN M f f 
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April 5, 1985 
Dr. Bernadine Healy Bulkley 
Deputy Director 
Office of Science and 
Technology Policy 
Executive Office of the 
President 
NEOB - Room 5005 
Washington, D.C. 20506 
Dear Dr. Bulkley: 
In response to the proposal of the Cabinet Council Working Group 
on Biotechnology published in the Federal Register on December 31, 
1984, a Working Group of the Recombinant DNA Advisory Committee 
does hereby desire to set forth certain recommendations and 
comments pertaining to said proposal. 
For 10 years RAC has been the only governmental body with actual 
experience in dealing with the problems presented by DNA and 
related biotechnology research. As such, RAC has gained a unique 
familiarity with its problems and opportunities. The members of 
RAC, and the staff at ORDA, have gairted considerable insight and 
perspective in dealing with specific applications from scientific 
investigators, as well as generic issues raised by industry, 
governmental agencies and the general public. 
Because of RAC's long-term involvement with the guidelines 
established for scientific research of recombinant DNA, it is 
appropriate that RAC respond to the proposals of your organiza- 
tion. It would be remiss if RAC failed to provide the benefits 
of our experience in this activity. The membership of RAC, both 
past and present, has developed an institutional memory which, 
hopefully, will be a resource to you in connection with these 
endeavors . 
[ 411 ] 
