Dr. Gottesrran cited her proposal to amend Section III-A-2 of the NIH Guidelines. 
Under the proposal, which will be considered by the RAC on September 29, Section 
III-A-2 would be amended to read as follows (underlined words represent changed 
wording): 
"III-A-2. Deliberate release into the environment of any organism containing 
recombinant DNA, except :- 
" a. Certain plants as described in Appendix L. 
" b. Deletion derivatives not otherwise covered by these Guidelines . 
" c. Organisms covered in exenption III-D-2 ." 
Dr. Landy moved that it be noted in the minutes that the working group discussed 
and recommends approval of the first part of Dr. Got tes man's proposed amendment 
of the NIH Guidelines dealing with deletion derivatives. The vote was eleven in 
favor, one opposed, and one abstention. 
Dr. Fedoroff moved that the working group support the second part of Dr. Gottes man's 
proposal dealing with organisms covered in exemption III-D-2. The vote was ten 
in favor, none opposed, and three abstentions. 
The working group then attempted to draft a sentence to be added at the end of 
Section I-B of the NIH Guidelines. Many possible versions of the sentence were 
considered. 
Dr. Landy then moved that the following sentence be added at the end of the first 
paragraph of Section I-B: 
"Genomes which contain only deletions, single-base changes, or rearrangements 
are not considered to be recombinant DNA irrespective of the method by 
which they were produced." 
The motion passed by a vote of eleven in favor, none opposed, and two abstentions. 
It was the sense of the working group that this is not intended to cover move- 
ment of plasmid or virus ENA into a chromosome, but it is intended to cover 
duplications, amplifications, or translocations. 
The working group then continued the discussion of deliberate release, and Dr. 
Vidaver moved that the following sentence be added at the end of Section III-A-2: 
"The term 'deliberate release' is defined as a planned introduction of 
recombinant DNA-containing microorganisms, plants, or animals into the 
environment." 
The vote was five in favor, four opposed, and one abstention. 
Dr. Gottesman then moved that Section III-A-2 of the NIH Guidelines be amended 
to read as follows: 
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Recombinant DNA Research, Volume 1 1 
