Mr. Mitchell then announced that three ad hoc members were in 
attendance at the meeting: Dr. Royston Clowes of the University 
of Texas, Dr. Robert McKinney of the NIH, and Dr. Gerard 
McGarrity of the Coriell Institute for Medical Research. He 
briefly touched on their professional expertise and welcomed 
their participation. 
II. MINUTES OF THE MEETING OF SEPTEMBER 29, 1986 
Mr. Mitchell then called upon Dr. LeRoy Walters to review the 
minutes of the September 29, 1986, meeting of the RAC (tab 1288). 
Dr. Walters said he had read the minutes and found them clear and 
complete; however, he felt some minor grammatical corrections 
should be made, not affecting the substance of the minutes, and 
he offered to take these up later with the Office of Recombinant 
DNA Activities (ORDA) staff. 
Dr. Bowman stated she had reviewed the minutes and moved that 
they be accepted. Dr. Davis asked whether such motion would 
allow for the grammatical corrections which Dr. Walters would 
recanmend, and Mr. Mitchell said snail stylistic changes not 
affecting the substance would be allowable under the current 
motion . 
Mr. Mitchell then put the motion to a vote. The motion passed 
unanimously with two members abstaining. 
Mr. Mitchell then stated that in light of the number of pertinent 
ccmments received after Mailings I and II had gone out, that it 
be appropriate for the RAC to take a short recess to allow 
members time to review fully these comments. Mr. Mitchell then 
recessed the committee for a half hour prior to discussion of the 
next agenda item. 
III. REPORT OF THE WORKING GROUP ON DEFINITIONS AND PROPOSED 
REVISION OF SECTION III-A-2 OF THE NIH GUIDELINES 
Mr. Mitchell reconvened the meeting at 9:45 a.m. and stated that 
this agenda item would include a discussion of materials 
contained in tabs 1285, 1286, 1288, and 1289. He further stated 
that an additional comment had just been handed to members which 
was received f ran the American Society for Microbiology. He said 
that in light of the Federal Register notice being published 30 
or more days prior to this meeting, that the RAC could take final 
action on this agenda item today and that discussion would be 
broken into two parts with Dr. McGarrity leading off the 
discussion. 
Dr. McGarrity stated that ORDA had asked the RAC Working Group on 
Definitions to examine the two terms “recombinant DNA" and 
"deliberate release" into the environment. The working group met 
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