“For large-scale (LS) fermentation 
experiments, the appropriate physical 
containment conditions generally need be no 
greater than those for the host organism 
unmodified by recombinant DNA techniques." 
The motion, being duly made and seconded, was approved by a vote 
of 13 in favor, none opposed, and 2 abstentions. It was noted 
that Dr. Johnson abstained from voting for reasons of potential 
conflict of interest. 
VII. REPORT FROM THE HUMAN G PI E THERAPY SUBCOMMITTEE 
Mr. Mitchell then called on Dr. Walters to present the report 
from the Human Gene Therapy Subcommittee. Dr. Walters reported 
that the Lay Language Working Group had met in January and 
developed a plan of action for producing a document entitled. 
Oversight of Research Involving Human Gene Therapy for Human 
Patients: General Information . He noted that Ms. Ann Witherby, 
who could not attend today's meeting because of illness in her 
family, had provided a copy of the working group report which had 
been distributed to all RAC members. The document to be produced 
will probably have four parts including: a brief explanation of 
how gene therapy will work; discussion of the general oversight 
framework of the Federal Government; a lay language summary of 
the Points to Consider in the Design and Submission of Human 
Scmatic-Cell Gene Therapy Protocols; and information about other 
publications and films available to the public for further 
information. Dr. Walters said the Human Gene Therapy 
Subcommittee would review this document at its April 24, 1987, 
meeting and that it was anticipated to be brought before the full 
RAC for review at the next RAC meeting. 
VIII. FUTURE MEETING DATES 
Dr. Gartland noted the only future meeting date currently 
scheduled was for June 15 , 19 87 . 
IX. ADJOURNMENT 
Having concluded the agenda and there being no further business 
to be discussed, Mr. Mitchell adjourned the canmittee at 3:25 
p.m. , on February 2, 1987. 
William J. Cortland, Jr. , Ph 
Executive Secretary 
Recombinant DNA Research, Volume 1 1 
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