uwbc 
University of Wisconsin Biotechnology Center 
Dr. Richard R. Burgess 
Director, UWBC 
1710 University Avenue 
Hadi son, WI 53705 
January 19, 1987 
Di rector 
Office of Recombinant DNA Activities 
Building 31, Room 3B10 
National Institute of Health 
Bethesda, HD 20892 
Dear Sir, 
I am writing in support of the Proposed Amendments of NIH Guidelines 
(51 FR 45650-45652). RAC has, in my opinion, served the citizens, 
scientists and businessmen of this country well by taking a cautious 
position with regard to the safety of recombinant DNA research and then 
relaxing the guidelines when experience shows that to be warranted. The 
proposed amendments, especially III and IV, are in that tradition. 
Amendment IV will have a tremendous positive effect on research and 
development at the University of Wisconsin, especially on projects 
associated with the Biotechnology Center. In addition, the biotechnology 
industry will be able to manufacture recombinant DNA derived protein 
products more efficiently and cheaply. 
I hope this evaluation and review by RAC will continue and that other 
regulatory agencies will also be cautious but reasonable. 
Sincerely yours. 
Richard R. Burgess 
RRB : jas 
Recombinant DNA Research, Volume 1 1 
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