IV. Die ASM concurs with the proposed revisions of Appendices C-II, C-III 
and C-IV. We believe that containment for low-risk microorganisms should be 
minimal and endorse the proposed change with the understanding that it does 
not include organisms otherwise covered under the guidelines and that the 
experiments performed will be consistent with good laboratory or 
manufacturing practice. 
We appreciate the opportunity to comment on these proposed actions under the 
Guidelines for Recombinant DNA Research. 
Sincerely, 
/^t IsfL&btuA — £). 
(On. S. ■ * 
Jean E. Brenchley, Ph.D. U 
President, American Society 
for Microbiology 
fetASOO 
Kenneth I. Be ms, M.D. , Ph.D. 
Chairman, Committee on Medical 
Microbiology and Immunology 
Harlyn Halvorson, Ph.D. 
Chairman, Public and Scientific 
Affairs Board 
Rudy J.ywodzinski, Ph.D. 
Chairman, Committee on Agricultural, 
Food and Industrial Microbiology 
[2S2] 
Recombinant DNA Research, Volume 1 1 
