33090 
NOTICES 
enous to the United States are in 
Class 3. except those listed in Class 
2. West Nile and Semliki Forest vir- 
uses may be classified up or down, 
depending on the conditions of use 
and geographical location of the 
laboratory.) 
Dengue rims, when used for trans- 
mission or animal inoculation ex- 
periments 
Lymphocytic chorimeningitis virus 
(LCM) 
Psittacosis-Omithosis-Trachoma 
group of agents 
Rabies street virus, when used in in- 
oculation of carnivores (See Class 
2 ) 
Ric/cettsia— all species except Vole 
rickettsia when used for transmis- 
sion or animal Inoculation experi- 
ments 
Vesicular stomatitis rims* 
Yellow fever rims— wild, when used 
in vitro 
D. CLASS 4 AGENTS 
1. Bacterial agents: None. 
2. Fungal agents: None. 
3. Parasitic Agents: None. 
4. Viral, rickettsial, and Chlamydial 
Agents: 
Alastrim, Smallpox, Monkey pox. 
and Whitepox, when used for 
transmission or animal inoculation 
experiments 
Hemorrhagic fever agents, including 
Crimean hemorrhagic fever 
(Congo). Junin. and Machupo vir- 
uses. and others as yet undefined 
Herpesidrus simiae (Monkey B 
virus) 
Lassa rims 
Marburg virus 
Tick-borne encephalitis rims com- 
plex. including Russian spring- 
summer encephalitis, kyasanur 
forest disease, Omsk hemorrhagic 
fever, and Central European en- 
cephalitis viruses 
Venezuelan equine encephalitis 
rims, epidemic strains, when used 
for transmission or animal inocula- 
tion experiments 
Yellow fever rims— wild, when used 
for transmission or animal inocula- 
tion experiments 
II. Classification of Oncogenic Viruses 
on the Basis of Potential Hazard 
( 2 ) 
A. LOW-RISK ONCOGENIC VIRUSES 
Rous Sarcoma 
SV-40 
CEXO 
Ad7 SV40 
Polyoma 
Bovine papoilloma 
Rat mammary tumor 
Avian Leukosis 
Murine Leukemia 
Murine Sarcoma 
Mouse mammary tumor 
Rat Leukemia 
Hamster Leukemia 
Bovine Leukemia 
Dog Sarcoma 
Mason-Pfizer Monkey Virus 
Marek’s 
Guinea Pig Herpes 
Lucke (Frog) 
Adenovirus 
Shope Fibroma 
Shope Papilloma 
B. MODERATE RISK ONCOGENIC VIRUSES 
Ad2-SV40 
FeLV 
HV Saimiri 
EBV 
SSV-1 
GaLV 
HV ateles 
Yaba 
FeSV 
III. Animal Pathogens (3) 
A. ANIMAL DISEASE ORGANISMS WHICH 
ARE FORBIDDEN ENTRY INTO THE 
UNITED STATES BY LAW (CDC CLASS S 
AGENT) 
1. Foot and mouth disease virus 
B. ANIMAL DISEASE ORGANISMS AND VEC- 
TORS WHICH ARK FORBIDDEN ENTRY 
INTO THE UNITED STATES BY USDA 
POLICY (CDC CLASS S AGENTS) 
African horse sickness virus 
African swine fever virus 
Besnoitia besnoiti 
Boma disease virus 
Bovine Infectious petechial fever 
Camel pox virus 
Ephemeral fever virus 
Fowl plague virus 
Goat pox virus 
Hog cholera virus 
Louping ill virus 
Lumpy skin disease virus 
Nairobi sheep disease virus 
Newcastle disease virus (Asiatic 
strains) 
Mycoplasma mycoides (contagious 
bovine pleuropneumonia) 
Mycoplasma agalactiae (contagious 
agalactia of sheep) 
Rickettsia ruminatium (heart 
water) 
Rift valley fever virus 
Rinderpest virus 
Sheep pox virus 
Swine vesicular disease virus 
Teschen disease virus 
Trypanosoma vivax (Nagana) 
Trypanosoma ev ansi 
Theileria parva (East Coast fever) 
Theileria annulata 
Theileria lawrencei 
Theileria bo vis 
Theileria hirci 
Vesicular exanthema virus 
Wesselshron disease virus 
Zyonema farciminosum (pseudo- 
farcy) 
References 
1. "Classification of Etiologic Agents 
on the Basis of Hazard.” (4th Edition. 
July 1974). U.S. Department of 
Health. Education, and Welfare. 
Public Health Service. Center for Dis- 
ease Control. Office of Biosafety. At- 
lanta, Ga. 30333. 
2. "'National Cancer Institute Safety 
Standards for Research Involving On- 
cogenic Viruses’" (October 1974). U.S. 
Department of Health. Education, and 
Welfare Publication No. (N1H) 75-790. 
3. U.S. Department of Agriculture. 
Animal and Plant Health Inspection 
Service. 
Appendix C— Table of Contents 
I. General Requirements. 
I- A. Institutional Biosafety Commit- 
tee (IBC). 
I- B. Approval and Registration of Pro- 
jects. 
II. Requirements and Procedures for 
NIH -Supported Projects. 
II- A. Memorandum of Understanding 
and Agreement (MU A). 
II-A-1. Contents of an MUA. 
II-A-l-a. Description. 
II-A-l-b. Assessment of Contain- 
ment Levels. 
II-A-l-c. Statement by principal 
investigator. 
II-A-l-d. Information Concern- 
ing IBC Review. 
II-A-l-e. Statement Regarding 
Continuing Compliance. 
II-A-l-f. Signatures. 
II-A-l-g. Date of MUA. 
II-A-2. MUA’s for Recombinant 
DNA Research at Multiple Sites. 
II-A-3. MUA's Associated with In- 
dividual Fellowship Applicants. Re- 
search Career Development Award 
Candidates (RCDA). Research 
Career Awardees (RCA), and Institu- 
tional National Research Service 
Fellowship Applications. 
II-B Submission of Memorandum of 
Understanding and Agreement 
(MUA). 
II-B-1. Competing Applications. 
II-B— 2. Noncompeting Applica- 
tions. 
II-C. Notation on Applications for Re- 
search and Training Grants. 
II-D. Award Procedures. 
II-E. Changes in Ongoing Projects. 
II-E-1. Protocols for Which Con- 
tainment Levels are Explicitly Speci- 
fied by the Guidelines. 
II-E-1 -a. Major Changes. 
II-E-l-b. Minor changes. 
II-E-2. Protocols for Which Con- 
tainment Levels are Not Explicitly 
Specified by the Guidelines. 
II-F. Shipping Requirements. 
III. Policy and procedures for Recom- 
binant DNA Research Supported by 
NiH and Conducted in Foreign Coun- 
tries. 
FEDERAL REGISTER. VOt. 43, NO 146— FRIDAY, JULY 28 1978 
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