CONTENTS 
Page 
Preface iii 
NIH-Proposed Revised Guidelines 1 
Letter from Donald S. Fredrickson, M.D., 
August 1 , 1 978 1 
Statement by Joseph A. Califano, Jr 3 
Introduction by Donald S. Fredrickson 3 
Decision of the Director, NIH, to Issue Revised 
Guidelines for Recombinant DNA Research 4 
Recombinant DNA Research— Revised Guidelines 
Proposed by the Director, NIH 30 
Environmental Impact Assessment of a Proposal 
to Release Revised NIH Guidelines for Research 
Involving Recombinant DNA Molecules 57 
Laboratory Safety Monograph — A Supplement to 
the NIH Guidelines (introductory matter only) 140 
Summary of Proceedings from Falmouth Workshop 
on Risk Assessment, by S. L. Gorbach 148 
[The following documents 
are in chronological order. ] 
Proposed Revised Guidelines — Recombinant DNA Molecule 
Program Advisory Committee (RAC) 162 
Letter from Donald S. Fredrickson, September 27, 1977 ... 162 
Recombinant DNA Research— Proposed Revised Guidelines . . 163 
Comments (see Appendix A) 
Director's Advisory Committee (DAC) Meeting, 
December 15-16, 1977 178 
Letter to Interagency Committee Members Confirming 
Telephone Invitation, November 15, 1977 178 
v 
