the December public hearing. In addition, the committee considered 
recommendations for revision of the Guidelines involving work with 
viruses and plant pathogens. The analysis and selected issues for the 
committee to review are included, along with a list of the RAC members. 
Correspondence related largely to proposed legislation follows, in- 
cluding an exchange of letters between Senator Edward M. Kennedy and 
NIH Director Donald S. Fredrickson on the nature of the limitations 
imposed by the NIH Guidelines on recombinant DNA research in the 
United States as compared with such research in other nations. 
A note is included on the status of the case Friends of the Earth v. 
Calif ano et al. 
Next are copies of Federal Register notices of public meetings and 
workshops held between February 19*75 and September 1978. 
The volume concludes with a chronology of major events associated 
with policy formulation involving recombinant DNA activities. The 
chronology extends from the Gordon Research Conference on Nucleic 
Acids, of July 1973, at which the capability to perform recombinant DNA 
experiments first aroused concern about potential hazards, to the antic- 
ipated promulgation of final revised Guidelines in November 1978. 
Appendix A, as noted above, includes all comments on the RAC- 
proposed Guidelines. 
Appendix B comprises significant congressional bills, reports, and 
testimony. Although several bills designed to lend the force of law to 
the NIH Guidelines have been filed in both House and Senate, no act of 
Congress has yet been passed. 
Appendix C is a compilation of legal documents in the case of Mack 
v. Califano et al., in which the plaintiff sought to enjoin NIH from con- 
ducting a risk -assessment experiment at the Frederick Cancer Research 
Center. The object of the experiment was to identify the factors that 
determine whether a viral DNA carried in a recombinant molecule can 
infect mice. Both the District Court of the District of Columbia and the 
U.S. Court of Appeals for the D. C. Circuit found in favor of the defen- 
dant, permitting initiation of the research. 
A fourth volume of this series is contemplated. It will contain the 
transcript of the September 15 public hearing on the proposed Guidelines 
and all comments received through September 26, 1978. It is also plan- 
ned to contain the final NIH Guidelines and other pertinent documents. 
iv 
