NOTICES 
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Appendix A 
COMPARISON OF TOE OOWTAINEeVT LEVELS OF HE 1976 GUIDQ.1NES 
AND TOE PROPOSED REVISED GUIDELINES 
IIGERfFD OfPv OOWAIfFIEW LEVELS 
RAC PROPOSED NIH DIRECTOR'S 
JUNE 1976 GUIDELINES REVISED GUIDELINES REVISED GUIDELINES 
PHYSICAL 
DIOLOGICAL 
PHYSICAL 
BIOLOGICAL 
PHYSICAL 
BIOIjOCICAL 
Shotqixi Experiments 
1. 
Primate 
P4 
EX2 
IM 
EEl 
P2 
EX2 1 
or P3 
EX3 
or P3 
EE3 
— 
— 
2. 
Primate DNA fra* uninfected 
cells 
— 
— 
P3 
EE2 
— 
— 
3. 
Qrtiryonic primate 
P3 
EE 2 
- 
- 
- 
- 
4. 
Manuals (other than primates) 
P3 
EK2 
P2 
EK2 
P2 
EX2 
5. 
Birds 
P3 
EE 2 
P2 
EE 2 
P2 
EX2 
6. 
Cold blooded vertebrates 
P2 
EE2 
P3 
EEl 
P2 
EXl 
or P2 
EE2 
or PI 
EX2 
7. 
embryonic and germ line 
P2 
EK1 
P2 
EXl 
— 
— 
or PI 
EX2 
8. 
producing potent toxins 
P3 
EE2 
- 
- 
- 
~ 
9. 
producing potent polypetide 
toxins 
— 
— 
P3 
EX2 
P3 
EX2 
Lower eukaryotes 
10. 
producing toxins, or are 
pathogens 
P3 
EE 2 
— 
— 
— 
— 
Shotqixi Experiments (Cont.) 
11. 
producing potent polypeptide 
toxins, or are pathogens 
— 
P3 
EX2 
P3 
EX2 
12. 
producing non-polypeptide 
— 
— 
P3 
EXl 
P3 
EXl 
' toxins 
or P2 
EX2 
or P2 
EX 2 
13. 
producing toxins affecting 
— 
— 
P3 
EXl 
P3 
EXl 
invertebrates or plants. 
or P2 
EX2 
or P2 
EX2 
14. 
remainder of species 
P2 
EXl 
P2 
EXl 
P2 
EXl 2 
or PI 
EX2 
or PI 
EX2 
IS. 
Plants 
P2 
FEl 
P2 
EXl 
P2 
EXl 
or Pl 
EX2 
or PI 
EX2 
16. 
cairying pathogens or making 
dang clous products 
P3 
EX2 
— 
— 
— 
17. 
cart/ing pathogens or making 
polypeptide toxins 
— 
P3 
EE 2 
— 
— 
18. 
making potent polypeptide toxins 
- 
- 
- 
— 
P3 
EX2 
19. 
making non- pol y pep* ide toxins 
— 
— 
P3 
EXl 
P3 
EXl 
or P2 
EX2 
or P2 
FX2 
FEDERAL REGISTER, VOL 43, NO. 146— FRIDAY, JULY 28, 1978 
[ 94 ] 
