33134 
NOTICES 
0CMTAR1SLH Of UK 0Q/TAIE#9Vr LEVEI.S OF HIE 1976 GUIDELINES 
AND HIE PROPOSED REV I SIX GUIDELINES 
INStimx IMA 
CTMTAIlKimT LEVEIS 
RAC PROPOSED NIH DIRECTOR'S 
JIWE 1976 GUIDELIESS 
REVISED GUIDELINES 
REVISEP GUIDELINES 
niYSICAf. BlOLfblLAL 
PHYSICAL BlOfOGICAL 
PHYSICAL BIOLOGICAL 
Prokaryotes exchanging genetic 
information with E. coll 
20. 
Cl 1 CDC agents 
PI 
EXl 
— 4 _ 
Pl 
EXl 3 
21. 
Clans 2 CDC agents 
n 
EXl 

P2 
EXl 3 
or T2 
EX2 
22. 
Prokaryotes not exdiangirxj genetic 
pi 
FX1 
See PrcAaryotic 
P2 
EXl 
InlnrxMt ion with E. coli 
or P2 
HC2 
IMA reocMbinants 
or Pl 
EX2 
(Categories 24-26) 
2J. 
It (Mttujenlc species 
Pl 
0(2 
Pl 
EX2 
Ptuftaiyotlc ISA reccabinants 
24. 
sruice of IMA is extensively 


P2 EXl 
. liar acte r I zed 
or PI EX2 
2*- 
sure* of ISA is nnt 


P2 EX 2 


extensively character lew! 
or PI EXl 
2b. 
snorce o t ISA Is fttlloy me 
species 
- 
— 
PJ 1X2 
- 
- 
Chat actor i zed clones 
it 
Species that exchange inform* 
PI 
fill 

See Characterized clones 
1 Ion with E. coll 
(Category 50) 
28. 
Species that A> not exchan e- 
1*2 
EXl 
See Character 1 zed clones 
See Characterized clones 
wilh E^ O'li 
(Category 40) 
(Category 50) 
29. 
Pis 1 fieri IMA other than 
One step reduction 
In p.ysical 
Same 
Same, except for prunate BA 
I’laswi.b, Uaclet lOfYkXjes, 
or biological containment f rox 
(See Footnote 11) 
xr»l nu«r Viriocsi 
that used in cor res pool l rg shot- 
9111 ci|^f iM.*nts 
Placenta, Bactr-r lopiages anil 
Other V irises 
10. 
Ammxl viruses 
P4 
EX 2 
See Categories 
• 
or PI 
EXJ 
12-41 
II. 
v4«.n clones shown to be 
Iree of harmful regions 
PJ 
EX 2 
See Categories 
• 
12-41 
Vunses of Warm-nicoled Vertebrates 
12 
IMA viruses ♦ transcripts of 


P4 EXl 
* 
retrovirus genomes 
or Pl EXJ 
FEDERAL RKWSTW. VOi. 43. HO. 144— FRIDAY, JUIY 28. 1978 
[ 95 ] 
