NOTICES 
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Appendix E 
TABLE 1 
Risk of Illness Ir. Laboratory Workers end of Spread of Viruses to the Environment 
Agent 
Genome 
Severity of 
Disease in 
Adult Humans 
Risk of 
Laboratory 
Infection 
Transmission 
Into 
Community or 
Environment 
Communl ty or 
Environmental 
Impact 
Laasa Fever Virus 
RNA - Negative strand, 
segmented 
4f 
H 
L - II 
H 
Vdriola Virus 
ON A - Linear, double 
stranded 
A* 
II (If not 
vaccinated) 
L - H 
H 
‘Ytr.jnia £es U s 
IPlagje bacterium) 
A* 
H 
L - H 
L - H 
VrllJu Fuser Virus (UIM type ) 
RNA - Positive strand 
3 r 
H ( If not 
vaccinated) 
Dependent on presence of vector (h 
*Ri l:.l r t s i a prowazfckl (Typhus agent) 
Jr 
II 
L 
0 
Hep it . t Is B Virus 
DIM - Circular, partially 
single stranded 
3f 
L to H 
L 
0 - L 
*V.b 1o ctjixja (Cholera bacterium) 
2t - 3t 
L 
L 
0 to L 
Influenza Virus (Novel epidemic strain) 
RNA - Negative strand, 
segmented 
If - 2* 
L 
H 
H 
ti->. icIr.-BjiT Virus 
D.NA - Linear, double 
stranded 
2t 
L 
L 
0 
Pi'Ho virus (wild) 
RNA - Positive strand 
0-34 
L 
L 
0 to L 
CcAScikle Viruses 
RNA - Positive strand 
0-2+ 
L 
L 
0 to L 
Herpes simplex virus 
DNA - Linear, double 
Stranded 
If 
L 
L 
0 
* Shi gel la sonnel 
If 
L 
L 
0 
Vesicular stomatitis virus 
RNA - Negative strand 
If - 2f 
H 
L 
L for humans; H for 
certain animals. 
AJ«.novirus 2 or 5 
DMA - Linear, double 
Stranded 
0 - u 
0 - L 
L 
0 
Ace no-SV^O Hybrid Viruses 
(Nondefecti ve) 
ONA - Linear, double 
stranded 
0 - It 
0 - L 
L 
0 
Vaccinia virus 
ONA - Linear, double 
stranded 
If 
L 
L 
0 
hurr.jn Papilloma virus 
DNA - Circular, double 
stranded 
If 
L 
L 
L to 0 
Influenza Virus (PR0) 
kHA - Negative strand, 
segmented 
0 
0 
0 
' 0 
*s.ic toro 1 Jos sp. 
0 - If 
0 
L 
0 
tdeno-assuLldted virus 
I'.IA - Linear, single 
stranded 
0 
L 
L 
0 
E»K Virus 
ONA - Circular, double 
s trended 
0 
L 
0 
0 
Simian Virus 40 (SV40) 
DMA - Circular, double 
stranded 
0 
L to H (?) 
0 to l(?> 
0 
Sindbls virus (Lab. adapted) 
RNA - Negative strand** 
0 - If 
0 
Dependent on 
presence of vector (0-L) 
Scn.l ikl Forest Virua 
RNA - Negative strand** 
0 - If 
0 
Dependent on presence of vector (0-L) 
Rtovlrjses 
RNA - Oouble stranded, 
segmented 
0 
0 to It 
0 
0 
Rous sarcoma virus 
RNA (Retrovirus) 
0 
0 
0 
0 
F.ui me leukunla sarcoma viruses 
RNA 
0 
0 
0 
0 
Feline leukemia viruses 
RNA 
0 
0 
0 
0 
Polyc.Tij virus 
DNA - Circular, double 
stranded 
0 
0 
0 
0 
4 Non-vlral agents. 
** EJ. note: This should read "RNA-Posltive strand." 
H • High probability; L • Low probability. 
FEDERAL REGISTER, VOL. 43, NO. 146— FRIDAY, JULY 28, 1978 
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