identifies specific training resources and provides a reference bibliography 
on biological safety. The monograph also includes guidelines for the control 
of moderate risk oncogenic viruses and information on packaging and shipping 
of recombinant DNA materials. 
Experience has demonstrated that the safe conduct of research involving 
potentially hazardous organisms is dependent on good laboratory practice, 
the availability and use of containment equipment, the design and operation 
of the research facility, and effective management. These are the subject 
areas to which this monograph has been addressed. It is hoped that this 
information will be of value to all concerned with the safe conduct of 
recombinant DNA research. 
Finally, the suggestions and reconmendations presented in the monograph 
are advisory in nature; they do not constitute mandatory requi rements . An 
important intent of the monograph is to encourage investigators, safety 
professionals and institutional officials to seek new and better methods of 
biohazard control and to apply professional judgement in the interpretation 
of the physical containment requirements of the "NIH Guidelines for 
Recombinant DNA Research." 
Note: This monograph names and illustrates representative materials, pro- 
cesses, and equipment only, and should not be considered as an all-inclusive 
listing. Names of coimercial manufacturers and trade names are provided as 
examples only, and their inclusion does not constitute or imply approval or 
endorsement; nor does the exclusion of commercial manufacturers’ names and 
trade names constitute or imply nonapproval or nonendorsement by the National 
Institutes of Health, Public Health Service, U.S. Department of Health, 
Education, and Welfare. 
2 
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