TABLE OF CONTENTS 
Summary Minutes of Director's Advisory 
Committee Meeting, December 15-16, 1977 i 
List of Participants xiv 
Part A — Comparison of NIH Guidelines for 
Recombinant DNA Research of June 
23, 1976, with the Proposed Revised 
Guidelines of September 27, 1977, prepared 
by the Office of the Director, NIH 1 
Definition of Recombinant DNA 2 
Physical Containment 3 
Biological Containment 5 
Prohibited Experiments 9 
Permissible Experiments 9 
Implementation 11 
Table: Comparison of Containment Levels 13 
Part B — Justification for Proposed Revisions 
of NIH Guidelines for Research Involving 
Recombinant DNA Molecules, prepared by 
the Recombinant DNA Molecule Program 
Advisory Committee 20 
Containment 21 
Experimental Guidelines 27 
Roles and Responsibilities 42 
Append ices 48 
References 49 
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