2 
CONTENTS 
Page 
Participants 5 
Opening Remarks by Dr. Fredrickson, December 15 6 
Introduction Section of the Proposed Revised Guidelines 
History of the Revisions (Dr. John Littlefield) 11 
Definition of Recombinant Molecules (Drs. 
Littlefield & Singer) 13 
The Concept of Novel Recombinations (Drs. 
Fredrickson & Spizizen) 15 
Committee Discussion of the Introduction Section 16 
Invited Witnesses — Presentations and Discussion 
Dr. Ronald Cape 18 
Dr. Bernard Davis 20 
Ms. Nancy Pfund 23 
Mr. Leslie Dach 28 
Public Witnesses — Presentations and Discussion 
Dr. Arthur Schwartz 31 
Mr. Scott Thacher . 32 
Ms. Francine Simring 34 
Dr. Jonathan King 39 
Dr. Wallace Rowe 43 
Dr. Mary-Dell Chilton 46 
Dr. Susan Wright 48 
Dr. David Gelfand 51 
Physical Containment Section of the Proposed Revised Guidelines 
Introduction to Physical Containment (Dr. 
Emmett Barkley) 51 
Committee Discussion of the Physical 
Containment Section 56 
Invited Witnesses — Presentations and Discussion 
Ms. Nancy Pfund 61 
Dr. David Gelfand 63 
Mr. Leslie Dach 68 
Public Witnesses — Presentations and Discussion 
Dr. Jonathan King 64 
Dr. Arthur Schwartz 7 3 
Ms. Francine Simring 77 
Dr. Bernard Davis 79 
Biological Containment Section of the Proposed Guidelines 
Introduction to Biological Containment (Dr. 
Susan Gottesman) 80 
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