43 
of the four Falmouth reports are corroborating references, they go along 
with published references. So I think we are getting the wrong impres- 
sion here. We have a strong data base here, and at least 18 of the 26 
references are published references, and only four of the 26 are from the 
Falmouth Conference. 
DR. FREDRICKSON: Thank you. 
Dr. Rowe, from the Recombinant Advisory Committee as well. 
DR. ROWE: As one of the organizers of the Falmouth Conference, this 
has come up here so much, if I may take three or four minutes to talk 
on the background of it, I think it is very important to set the record 
straight . 
DR. FREDRICKSON: Does the Committee wish to hear this? 
MR. HUTT: Yes. 
DR. FREDRICKSON: Would you please come to the podium, Dr. Rowe. 
DR. ROWE: The Falmouth Conference was an outgrowth of a realiza- 
tion by Malcolm Martin and me, as it involved people here at NIH, that an 
amazingly important segment of the biomedical community had not been heard 
from in the initial discussions on the subject, and that is the people who 
knew what intestinal infection, what colonization of E. coli was all about- 
people who know the epidemiology, the pathogenesis, the serological factors 
the clinical disease, the worldwide biology of Escherichia coli and other 
enteric bacterial infections. 
Malcolm and I organized a group of consultants to come in to give 
us advice on — primarily for me as a member of the Committee — on what the 
Committee should do about getting this very important input that we felt 
was missing, that the infectious disease people had not yet gotten into 
the debate, where at this level of time the debate is primarily a problem 
in infectious disease. We called in people, had a meeting. We had it 
taped and we put out informally the proceedings of that meeting as an un- 
official transcript, and it has been widely disseminated. It is an inter- 
esting historical document. 
We realized from this that there was an awful lot of information — 
published primarily, but in part unpublished — that is disseminated through 
the infectious disease literature which was amazingly relevant to the 
problems we were up against. We didn't know this: that people have tried, 
by standard genetic crosses, to put genes into E. coli either to try to 
make vaccines by introducing serological antigens from a pathogen into 
K-12 or to study what genes transferred in would convert it to a pathogen. 
We found out, to our great surprise, that they could not create a pathogen 
out of K-12. We said this is very important information, let's get broader 
input on it. We ought to have a workshop. 
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