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minimum attention given to environmental issues that evidently went into the 
development of the NIH Guidelines, into the draft Environmental Impact State- 
ment, and the various public and scientific discussions." They recommended — 
and I feel this is very important, because so many people have said, Where 
is the data for survivability in the soil and water and so forth? — they 
recommended: "Model experiments should be conducted with labeled organisms 
to determine their survival and fate in representative test waters, soils, 
and air samples." They also recommended that "survivability studies with 
the host strain prior to insertion of new genetic materials should precede 
all recombinant DNA research with that host." 
Once again, we are forced to remark that critical comments have not been 
reflected in the Environmental Impact Statement and in the proposed revised 
Guidelines. I do hope that many of these critiques will be considered in 
the further drafting of the proposed revised guidelines and in all the subse- 
quent discussions. 
Thank you very much. 
DR. FREDRICKSON: Thank you, Ms. Simring. 
Mr. Hutt. 
MR. HUTT: That is the second time today that a question was raised 
about the adequacy of the analysis in response to specific comments. It 
was suggested earlier by Dr. Fredrickson, and I hope facetiously, that the 
way that the Committee members could pursue that is to read this volume and 
then having analyzed that, to then read this volume and make sure that this 
one answered all the questions in this one. I don't propose to do that 
this evening. I was wondering if the two speakers who raised those criti- 
cisms, in all seriousness, could give us specific examples. I wouldn't ask 
you to list every place where you think it is inadequate, but if you could 
point out specific pages where comments are made in here on which there is 
no analysis in here, because the Committee can't possibly undertake that on 
its own. 
DR. FREDRICKSON: Could you do that perhaps over the night, Ms. 
Simring? 
MS. SIMRING: I will tell you frankly, I had hoped to get some sleep 
tonight; we got so little last night. And as I had indicated, we got these 
materials so late. There are some 500 or so pages. I skimmed through them. 
However, they will be analyzed and be available for the written record. 
MR. HUTT: But in order for you to have made the statement that there 
are inadequacies, I am not asking for all of them, just examples, and I 
agree, I am happy to defer to the chairman's suggestion that it be done 
tomorrow. 
MS. SIMRING: All right, I will select some of the examples that would 
support that. 
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