259 
are some specific things included in the proposals which weren't in the 
original Guidelines, and that is good, but with regard to monitoring previ- 
ously approved research projects in an institution, what sorts of things 
must they monitor, how often must they be monitored, and this sort of thing. 
That is the extent of my comments. 
DR. FREDRICKSON: Thank you, Mr. Beaty. 
Reserving the fact that, should you be negative in your answer, it 
doesn't mean you approve of everything, did you find any revisions that were 
proposed that you would immediately oppose yourself? 
MR. BEATY: Yes. 
DR. FREDRICKSON: Did you state those, or will you state those to us? 
MR. BEATY: I have one very specific one, and that regards changing the 
work with Agrobacterium tumefaciens from a P2+EK2 to P3+EK2. 
DR. FREDRICKSON: You oppose that increase in containment? 
MR. BEATY: Yes, I do. 
DR. FREDRICKSON: I see. 
Dr. Neel, a Professor of Human Genetics at the Unversity of Michigan. 
I hate to remind you who you are every time I go around, but I think for the 
record it is important. so that others will know your perspectives again. 
DR. NEEL: I have two suggestions which I will arrive at somewhat circui 
tously, as I tried to, no doubt, this morning. I was under the impression 
that the moratorium, if I could use that term, the moratorium that arose at 
the time of the Asilomar conference was in part motivated by fear of unknown 
epidemics, but in part by a certain humility concerning the power of these 
techniques, which involve the ability to create new life forms, literally. 
Now, I happen to work with what is euphemistically called a higher eukaryote, 
and that is, all of you — people — and my concern with recombinant DNA research 
then, somewhat understandably focuses on this, and the extraordinary range of 
possibilities which are now developing in this particular area. Our Guide- 
lines deal entirely, it appears, with recombinant DNA research where viruses 
or plasmids are used as the vectors; but as you know, there are now cell 
fusion techniques and, beyond that, the introduction of parts of human 
chromosomes into the mouse genome, using what are called 1 i pochromosome s 
to effect the transfer, which are opening up to me a mind-boggling array of 
research potentialities. 
Now, I don't think there is any time to spin out the science-fiction- 
type scenarios which exist here, but there are some very interesting possi- 
bilities. I think, Dr. Fredrickson, history might judge us a little bit 
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