260 
harshly at this stage in the unfolding problem if we fail somehow to take 
cognizance of the fact that we are dealing with, to me, only a small piece 
of recombinant DNA research at the present time. At the very least, now 
that you have set the precedent of these Guidelines, I would predict within 
two or three years you will have the need thrust upon you for guidelines 
in these other areas of recombinant DNA research. How much of the human 
genome has to be transferred to a mouse before we begin to get into a very 
interesting problem? 
I would suggest that the Director's preamble to all of this recognize 
more specifically than it does that this particular set of recommendations 
addresses only a very limited portion of the whole area of recombinant DNA 
research. I would further wonder if we couldn't find a somewhat more speci- 
fic title than the present one. It would, of necessity, be more cumbersome, 
but this is a very broad title — Recombinant DNA Research--and I think we 
will be criticized if so much of what is recombinant DNA research is nowhere 
mentioned in this Guideline. 
DR. FREDRICKSON: Do you in general favor some form of revision of the 
Guidelines of '76 at this time? 
DR. NEEL: I am happy with the proposed revisions with what I have heard 
in the way of suggestions here. My recommendations are for the title and for 
your introductory preamble. 
DR. FREDRICKSON: Thank you, Dr. Neel. 
Dr. Harold Ginsberg is presently on sabbatical at Rockefeller University, 
but when he is home he is the Chairman of the Department of Microbiology at 
Columbia College of Physicians and Surgeons. 
Dr. Ginsberg. 
DR. GINSBERG: Thank you, Dr. Fredrickson. 
I have only a few quarrels with the revised Guidelines. I believe that 
they are still in a few areas unnecessarily restrictive. I would prefer to 
see research that requires P1+EK1 not included. I think again, it adds much 
to the work of the local biosafety committees for essentially little return, 
and also to your own committees. I think that more attention could be 
turned to more important matters if those large numbers of experiments were 
eliminated . 
DR. FREDRICKSON: But, Dr. Ginsberg — excuse me for interrupting you, 
but do you mean that by the adoption of these proposed revisions, we will 
eliminate a certain number whose elimination you favor, or you would — 
DR. GINSBERG: I would eliminate even more. 
DR. FREDRICKSON: Even more? 
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