novel exchangers that are subject to the Guidelines; 
• that the procedures and criteria used in the development 
2 
of the list be explained thoroughly and that adequate oppor- 
tunity be given for public review and comment; 
• that all data pertaining to the inclusion of each entry on the 
list be available for public review. 
ISSUES FOR THE COMMITTEE'S CONSIDERATION 
The extensive public comment on this section included recommenda- 
tions that there be a general applicability, exemption, and definition 
section. Accordingly, I am suggesting that such a section be included 
in Part I, the Introduction. Further, I propose that the section on 
prohibited experiments be transferred from Part III to Part I. Thus, 
Part I would establish the jurisdiction of the Guidelines, their 
applicability, and the experiments that are prohibited and exempt. 
The following suggestions also arise from my review: 
• In your Committee's proposed revision, the purpose of the Guide- 
lines is to "establish procedures for handling organisms and 
viruses containing recombinant DNA molecules." In the current 
Guidelines the purpose speaks to "research with recombinant 
DNA molecules." It was noted in our review that your recommenda- 
tion might inadvertently have the effect of removing from the 
list of prohibited experiments those in which recombinant DNA 
molecules were created from the DNA of certain pathogens even 
though this DNA was not contained witnin an organism. Because 
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