II- 27-28-MINLTTES OF MEETING 
7 
detail. Votes were taken on acceptance of the lists 
or of the principles used to construct the lists. 
When Dr. Falkow presented his lists on the first day 
of the meeting, adoption of his Table 4 (similar to 
Attachment rv-A) , was rec amended unanimously by the 
RAC as a list for exemption iv. The principles used 
in creating Dr. Falkow' s Table 3 (which is the same 
principle used to construct Attachment IV-B) , was 
reccrmended by the RAC (by a vote of 9 to 3) as basis 
for the exemption iv list. A motion to accept 
Dr. Falkow' s Table 1 with specified modifications 
(which is very similar to Attachment IV-C), as the 
exemption iv list, passed by a vote 7 to 5. 
There was an opinion expressed by a member of the RAC 
that pathogens such as Neisseria gonorrhoeae should 
not be on the list. However, Dr. Adelberg reminded 
the RAC the concept had been introduced in the proposed 
revised Guidelines of excluding from the Guidelines 
non-novel recombinant DNA whether or not CDC Class 2 
pathogens were involved. A motion that criteria of 
genetic exchange be applied in developing the list 
for exemption iv and that pathogenicity (i.e., CDC 
Class 1 vs. Class 2) not be considered relevant in 
this context (recognizing that use of Class 3, 4, and 
5 CDC agents is prohibited) passed unanimously. 
On the second day, Crs . Hel inski and Spizizen presented 
revised lists based on the same concepts as the three 
Falkow lists, but embodying some changes in the lists 
themselves, and the RAC made further slight amendments. 
The three final alternate lists are attached as Attachments 
IV-A, IV-B, and IV-C. With each of the alternate lists, 
any organisms appearing on the list are to be considered 
"exchangers" and therefore any recombinant DNA molecules 
composed entirely of DMA segments coming from any members 
of the list, to be propagated in any member of the list, 
would be exempted under exemption iv. (One exception 
to this is in Table IV-C where H. influenzae and H. 
para influenzae form a two-membered list separate from 
the main 19-membered list.) 
Given at the top of each list is a description of the 
criteria used to construct the list. Thus the Attachment 
IV-A list is composed of "organisms of the Enterobacteriaecae 
family which exhibit chromosomal DNA relatedness (20% or more 
homology of CNA of various pairs tested) and genetic recom- 
bination of R-prime (R plaatid carrying chromosomal genes) 
transfer to E. coli K-12 mediated by the IncP-1 plasmids." 
The larger Attachment IV-B list includes all the members 
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