APRIL 27-2 8-MINUTES OF MEETING 
10 
A motion passed unanimously that the RAC expressed its willingness 
to review proposals from private industry and provide the necessary 
confidentiality, provided that the sutmitter agreed to abide by 
the standards of the NIH Guidelines. 
J. This item was covered during the discussion of viruses (see below). 
K. The RAC accepted the recommendation that the Guidelines provide 
that the Director, NIH, on the recommendation of the RAC, may 
designate certain of the agents listed as Class 2 (in the CDC's 
Classification of Etiologic Agents on the Basis of Hazard) to 
be considered as Class 1 agents for the purposes of these 
Guidelines. 
L. The RAC accepted these recommendations and made added suggestions. 
s The Section on "Prokaryotic DNA Recombinants" (i.e.. Section 
hi. III-B-I-a (2) of the proposed revised Guidelines) should read: 
" (2) Prokaryotic DNA Recombinants 
(a) Prokaryotes that exchange genetic information 
with E. coll . It is expected that prokaryotes 
that exchange genetic information with EL ooli 
will be exempted from these Guidelines by appearing 
on the 'list of exchangers' (see exemption iv) . 
For those not on the list, the containment 
levels are Pi physical containment + an EKl 
host-vector. In fact, experiments in this 
category can be performed with EL coli K-12 
vectors exhibiting a lesser containment 
(e.g., conjugative plasmids) than EKl vectors. 
However, for prokaryotes that are classified 
as Class 2 (footnote) in reference 5, the 
containment levels are P2 + EKl. 
(b) Prokaryotes that do not exchange genetic infor- 
mation with E. coli . P2 physical containment + 
an EKl host-vector or Pi + EK2 except for ENA 
from CDC Class 2 (reference 5) agents (footnote) 
which require P3 + EK2." 
N. The RAC accepted the addition to the Guidelines of a Section 
dealing with synthetic DNA. The proposed language in Attachment 
II was accepted with seme modifications. This Section vould 
read: 
"Synthetic DNAs 
"If tnd synthetic ENA segment can or might yield a potentially 
harmful polynucleotide or polypeptide (e.g., a toxin or a 
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