APRIL 27-28-MINLTES OF MEETING 
13 
Y. The RAC accepted this suggestion that the biological safety 
officer be a member of the IBC. 
Z. The RAC accepted this suggestion (that a section on penalties 
be included and that it be stated that violation of the NIH 
Guidelines may result in suspension, limitation, or termination 
of NIH grants or contracts). Dc . Red ford preferred that it 
state that the suspension, limitation, or termination would be 
for NIH recombinant DNA research grants or contracts, i.e., 
not to include totally extraneous grants or contracts. 
AA. The RAC accepted this suggestion of including a registration 
section. 
BB. The RAC accepted this suggestion to permit voluntary "registration 
and certification by institutions in the private sector." The 
concept was reiterated that if NIH is performing a service for 
industry, we should expect in return their agreement to follow 
the standards of the Guidelines. 
CC. The RAC accepted the inclusion in the Guidelines of "a provision 
on disclosure of information that would set general policy guide- 
lines in regard to patents." 
III. EK2 HOST-VECTOR SYSTEMS 
A. Plaanid Systems 
Dr. Alelberg summarised the deliberations of the plasmid Working 
Group which had met on April 26. 
1. .,2282 
The RAC voted unanimously to recommend approved of x2282 for 
use as an EK2 host in place of \1116 for the cloning of the 
mouse dihydro folate reductase gene, provided that an approved 
EK2 vector is used. 
The Committee noted that Dr. Cohen has submitted data showing 
that the thyA + character has not decreased the sensitivity 
of x2282 to DAP deprivation or to bile salts. The thyA + 
character should not alter the ability of x2282 to meet 
criteria for transmissibility, since the transmission tests 
that are required are done in the presence of thymidine. 
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