I. CALL TO ORDER AND INTRODUCTORY REMARKS. 
Mr. Mitchell, Chair, called the meeting of the Recombinant DNA 
Advisory Committee (RAC) of the National Institutes of Health 
(NIH) to order at 9:00 a.m. , September 21, 1987. He said the 
meeting was called pursuant to a Federal Register notice which, 
being 30 or more days prior to today's date, met requirements of 
the NIH Guidelines for Research Involving Recombinant DNA 
Molecules. He stated that the meeting would remain open to the 
public for its entirety, and that he expected the meeting to 
conclude within one day. 
Mr. Mitchell asked Dr. Gartland if a quorum was present and 
Dr. Gartland assured the Chair that a quorum was in attendance. 
Mr. Mitchell noted that he intended to make every effort to abide 
by the distributed agenda with respect to time estimates for each 
item of business. He reminded the committee that in recognizing 
persons for comments he would use the following order: primary 
and secondary reviewers on each item as set forth in the agenda; 
other members of RAC; ad hoc consultants to the RAC; NIH staff 
members ; members of the public who had submitted written 
comments; and finally, other members of the public. He 
underlined that RAC was advisory to the Director of NIH; and in 
light of this, persons with minority opinions should voice them 
so as to provide Dr. Wyngaarden with the entire spectrum of 
opinions on a given topic. Mr. Mitchell then told the committee 
that in all voting he would call first for the affirmative, then 
for the negative, and finally for abstentions. He underlined 
that if any voting member felt compelled to abstain due to 
conflict of interest, that such member should notify the Chair so 
that the record could duly reflect such. 
Mr. Mitchell then made note of Mailings I and II which were sent 
to members prior to the meeting. He also noted that the recently 
received materials were supplied at the table for each member. 
Mr. Mitchell said that the reason the June meeting had been 
cancelled was that the RAC Working Group on Revision of the 
Guidelines had not finished its work on the proposed addition of 
plant and animal containment to the NIH Guidelines. He then 
introduced the four ad hoc consultants: Drs. Stephen Hughes, 
John Richardson, Nina Fedoroff , and Gerard McGarrity. 
II. APPROVAL OF THE MINUTES OF THE FEBRUARY 2, 1987, MEETING. 
Mr. Mitchell called on Dr. Musgrave to report on the minutes of 
the February 2, 1987, meeting of the RAC. Dr. Musgrave said he 
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Recombinant DNA Research, Volume 13 
