7054 
Federal Register / Vol. 53, No. 43 / Friday, March 4, 1988 / Notices 
Dated: February 24. 1983. 
James B. Wyngaardea. 
Director. National Institutes of Health. 
[FR Doc. 80-5714 Filed 3-3-80: 8:45 am] 
Billing ccce nis-r.-u 
Recombinant DNA Advisory 
Committee Working Group on 
Transgenic Animals; Meeting 
Pursuant to Pub. L. 92—463, notice is 
hereby given of a meeting of the 
Recombinant DNA Advisory Committee 
Working Group on Transgenic Animals 
at the National Institutes of Health, 
Building 3lC, Conference Room 9, 9CQ0 
Rockville. Pike, Eethesda, Maryland 
20692, on March 28, 1988, from 
approximately 9:00 a.m. to adjournment 
at approximately 5:00 p.m. to review 
guidelines for recombinant DNA 
experiments involving transgenic 
animals. This meeting will be open to 
the public. Attendance by the public will 
be limited to space available. 
Further information may be obtained 
from Dr. William J. Gartland, Executive 
Secretary, Recombinant DNA Advisory 
Committee Working Group or. 
Transgenic Animals, Office of 
Recombinant DNA Activities, 12441 
Parklawn Drive, Suite 58, Rockville. 
Maryland 20852. telephone [301) 770- 
0131. 
OMB's “Mandatory Information 
Requirements for Federal Assistance 
Program Announcements” (45 FR 39592) 
requires a statement concerning the 
official government programs contained 
in the Catalog of Federal Domestic 
Assistance. Normally NIH lists in its 
announcements the number and title of 
affected individual programs for the 
guidance of the public. Because the 
guidance in this notice covers not only 
virtually every NIH program but also 
essentially every Federal research 
program in which DNA recombinant 
molecule techniques could be used, it 
has been determined to be not cost 
effective or in the public interest to 
attempt to list these programs. Such a 
list would likely require several 
additional pages. In addition, NIH could 
not be certain that every Federal 
•program would be included as many 
Federal agencies/as well as private 
organizations, both national and 
international, have elected to follow the 
NIH Guidelines. In lieu of the individual 
program listing. NIH invites readers to 
direct questions to the information 
address above about whether individual 
programs listed in the Catalog of 
Federal Domestic Assistance are 
affected. 
Date: February 29. 1988. 
Betty J. Beveridge. 
Committee Management Officer. NIH. 
[FR Doc. 83-4715 Filed 3-3-38: 8:45 am] 
BILLING CCCE 414C-01-U 
Public Health Service 
National Toxicology Program; 
Announcement of Completed Short- 
Term Toxicology Studies cn Eight 
Chemicals; Request fcr Comments 
As part of an effort to inform the 
public and allow interested parties to 
comment and provide information on 
chemicals prior to designing studies for 
long-term toxicology and carcinogenesis 
studies, the National Toxicology 
Program (NT?) routinely announces in 
the Federal Register the list of chemicals 
for which short-term toxicology studies 
have been completed. 
Short-term toxicology studies on the 
chemicals listed in this announcement 
have been completed and the National 
Institute of Environmental Health 
Sciences [NIEHS)/National Toxicology 
Program (NTP) is in the process of 
evaluating the results. A decision on 
whether additional studies are needed, 
including long-term toxicology and 
carcinogenicity studies, will soon be 
made by the NTP. If you have relevant 
information (such as current production, 
use pattern, exposure levels, 
toxicological data) to share with the 
NTP on any of these chemicals, please 
contact the responsible NT? Scientist 
within 30 days of the appearance of this 
announcement. Contact may be made by 
telephone or mail to: NIEHS/NTP, P.O. 
Box 12233, Research Triangle Park, 
North Carolina 27709. The information 
provided will be considered by the NTP 
in determining which chemicals require 
additional studies and in designing these 
studies. 
1. Acetone (67-64-1) — 14-day and 90- 
day dosed water studies in Fischer 344 
rats and B6C3Fi mice. Contact Person: 
Dr. Dennis Dietz, telephone 919-541- 
2272. 
2. t-Butyl alcohol (75-65-0) — 90-day 
inhalation studies in Fischer 344 rats 
and B6C3Fi mice. Contact Person: Dr. 
Robert Maronpot, telephone 919-541- 
4861. 
3. 12-Dichloroethane (107-06-2) — 90- 
day dosed water studies in Fischer 344, 
Sprague Dawley, and Osborne Mendel 
rats and B6C3Fi mice and 90-day gavage 
studies in Fischer 344 rats. Contact 
Person: Dr. Elmer Rauckman. telephone 
919-541-7981. 
4. Isobutyl nitrite (542-56-3) — 14-day 
and 90-day inhalation studies in Fischer 
344 rats and B6C3Fi mice. Contact 
Person: Dr. Carlton D. Jackson, 
telephone 501-541—4553. 
5. 3-Methyl-6-methoxy-2-amina- 
Jjeryolhiazo/ium chloride . 
(NOCAS0884) — 14-day and 90-day 
dosed feed studies in Fischer 344 rats 
and B6C3Fi mice and 14-day gavage 
study in male Fischer 344 rats. Contact 
Person: Dr. Elmer Rauckman, telephone 
919-541-7981. 
6. Phenolphthalein (77-09-8) — 90-day 
dosed feed study in Fischer 344 rats anc 
E6C3Fi mice. Contact Person: Dr. Denni 
Dietz, telephone 919-541-2272. 
7. 1^.4. 5-Tetra chlorobenzene (95-94- 
3) — 14-day and 90-day dosed feed 
studies in Fischer 344 rats and B6C3Fi 
mice. Contact Person: Dr. Raymond 
Yang, telephone 919-541-2947. 
8. Tetrahydrofuran (109-99-9) — 90- 
day inhalation studies in Fisher 344 rats 
and B6C3Fi mice. Contact Person:. Dr. 
Raj Chhabra. telephone 919-541-3386. 
Please submit all comments and 
suggestions on chemical(s) by telephone 
or by mail to the responsible scientists 
(listed above) within 30 days of 
publication of this notice. Any 
submission received after the above 
date will be accepted and utilized if 
possible. 
Dated: February 26. 1983. 
David P. Rail, 
Director. Nationcl Toxicology Program. 
(FR Doc. 83-4713 Filed 3-3-88: 8:45 am] 
BILUNG CODE 4140-01-U 
National Toxicology Program; 
Availability of Technical Report on 
Carcinogenesis Studies of Food Grade 
Geranyl; Acetate 
The HHS' National Toxicology 
Program today announces the 
availabilty of the Technical Report 
describing the carcinogenesis studies of 
geranyl acetate, a colorless liquid 
prepared by fractional distillation of 
selected essential oils or by acetylation 
of geraniol. It is used primarily as a 
component of perfumes for creams and 
soaps and as a flavoring ingredient. 
Carcinogenesis studies of food-grade 
geranyl acetate (containing 29% 
citronellyl acetate) were conducted by 
administering the test chemical in com 
oil by gavage to groups of 50 male and 
50 female F344/N rats at doses of 0, 
1,000 or 2,000 mg/kg body weight and to 
groups of 50 male and 50 female B6C3Fi 
mice at doses of 0, 500 or 1,000 mg/kg. 
Doses were administered five times per 
week for 103 weeks. 
Under the conditions of these studies, 
geranyl acetate was not carcinogenic for 
F344/N rats or B6C3Fi mice of either 
sex; however, the reduced survival 
[114] 
Recombinant DNA Research, Volume 13 
