ad hoc consultant in the past and he underlined the "blending" 
brought about by Dr. Fredrickson's decision to appoint lay 
members to the committee, which has added broad-based viewpoints 
and perspectives to the workings of the committee and added 
greatly to the success of the group. 
Dr. McGarrity then introduced Dr. Susan Gottesman, Mr. Robert 
Lanman, and Dr. Robert McKinney, who were the ad. hoc consultants 
to the committee for this meeting. 
Dr. McGarrity called upon Mr. earner to present the minutes of 
the meeting of September 21, 1987. 
II. APPROVAL OF THE MINUTES OF THE FEBRUARY 2, 1987, MEETING. 
Mr. earner said he had no additions or corrections to the 
minutes. However, Dr. Johnson said he felt the wording on page 
16 of the minutes should be clarified to meet the intention of 
the comment which was that the NIH counsel be a part of the 
working group, rather than any request by Dr. Johnson that he 
himself be on the working group. 
Dr . Korwek said portions of the minutes on page 9 needed to be 
reworded concerning the NIH Guidelines and the National 
Environmental Policy Act (NEPA) and that he would speak with 
staff about such changes to simply clarify his intent. 
There being no other additions, deletions or alterations. Dr. 
McGarrity called for approval of the minutes by voice vote which 
was unanimous . 
Dr. McGarrity called on Dr. Cohen as primary reviewer to discuss 
Item Number III, the proposed amendments of the NIH Guidelines 
regarding transgenic animals. 
III. PROPOSED AMENDMENTS OF NIH GUIDELINES REGARDING TRANSGENIC 
ANIMALS (tabs 1310/IV, 1321, and 1322). 
Dr. Cohen said the Working Group on Transgenic Animals had met on 
March 28, 1988, and discussed two basic issues: 
1. whether the NIH Guidelines for Research Involving 
Recombinant DNA Molecules should be revised 
regarding coverage of transgenic animals; and, 
2. containment guidelines for experiments involving 
the introduction of recombinant DNA into the 
genome of animals, particularly introduction of 
DNA from human pathogens. 
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Recombinant DNA Research, Volume 13 
