Dr. Korwek said he still had a problem with expansion of the 
applicability of the NIH Guidelines beyond recombinant DNA but 
because of this being a new area he felt it needed further 
discussion. 
Dr. Gottesman suggested a sense of the committee be taken on the 
issue of pursuing a change in the definition of "recombinant 
DNA," or the title of the NIH Guidelines. Dr. Korwek said he 
preferred to leave the definition alone because it is used 
throughout the NIH Guidelines and further problems could be 
created by any change in definition. Further, he said he was 
not in favor of the language as currently exists in 
Recommendation D because it covers non-recombinant DNA 
transgenics . 
Dr. Atlas moved that Recommendation D be amended to include the 
phrase "recombinant DNA, or DNA or RNA derived therefrom" in 
place of the term "DNA" in the first sentence. It would 
therefore read: 
"This section covers experiments involving whole 
animals, both those in which the animal's genome has 
been altered by stable introduction of recombinant DNA, 
or DNA or RNA derived therefrom, into the germ line 
(transgenic animals) and experiments involving viable 
recombinant-DNA-modif ied microorganisms tested on whole 
animals . " 
Dr. Mannix seconded the motion. Dr. Neiman accepted this 
language as a "friendly amendment," and Dr. Erickson concurred. 
Dr. Gartland suggested the use of the word "molecules" to 
standardize this phrase with its use in Recommendation F. Dr. 
Davis noted that RNA cannot be incorporated into the genome of an 
animal and therefore it should be dropped. Dr. Gellert said if 
"RNA" were removed then the word "molecules" was unnecessary 
because that referred to the RNA. 
The final wording agreed upon for this sentence then became: 
"This section covers experiments involving whole 
animals, both those in which the animal's genome has 
been altered by stable introduction of recombinant DNA, 
or DNA derived therefrom, into the germ line 
(transgenic animals) and experiments involving viable 
recombinant-DNA-modif ied microorganisms tested on whole 
animals . " 
There being no other amendments to the motion. Dr. McGarrity put 
the motion to a vote. The motion passed by a vote of 20 in 
favor, none opposed, and no abstentions. 
Recombinant DNA Research, Volume 13 
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