Clinically the animal has been normal except for transient adenopathy which 
has resolved. Exam at 84 days is normal with continued normal complete blood 
count and blood chemistries. 
Summary : Exposure to murine retrovirus through infected fibroblasts in 
combination with intraperitoneal injection of retrovirus led to a productive 
infection of primate lymphocytes in vivo . To date the animal has shown no 
sequelae from the exposure. Detectable virus had disappeared by day 84 and 
coincided with the appearance of p30 antibodies. 
Conclusion : Murine amphotropic retroviruses can infect primate cells in vivo and 
cause a productive infection in lymphocytes. Transient lymphadenopathy is the 
only clinical finding noted and no detectable virus was found after the 
development of antiviral antibodies. Our data preliminary data suggests that an 
exposed patient would not suffer any acute clinical illness and would not present 
a public health risk. Information about the long-term consequences of such an 
exposure will require continued observation of these animals. Since TIL can be 
extensively studied in vitro prior to patient exposure, we believe likelihood of 
retrovirus exposure for participant in our protocol is very unlikely. 
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Recombinant DNA Research, Volume 13 
