SIR WILLIAM DUNN SCHOOL OF PATHOLOGY 
UNIVERSITY OF OXFORD 
SOUTH PARKS ROAD. OXFORD 0X1 3RE 
Telex 83147 viaor G- 
TELEGRAMS Attn DUNPATH 
Fax 0865 - 270708 
TELEPHONE 
DIRECT LINE 
Oxford (0865) 275571 
(Secretary) 275573 
May 16 1988 
Dear Dr Gartland 
Large scale production involving 
Ceohalospor ium acremonium strain LU-4-796 
I am engaged in a collaborative project with Eli Lilly and 
Company, Indianapolis, and Professor J E Baldwin of the 
Dyson Perrins Laboratory, Oxford, relating to the 
biosynthesis of cephalosporins and penicillins. 
In this capacity I am writing to you in support of Eli 
Lilly's request for approval to carry out large scale 
experiments and production involving the above strain of 
Cephalospor ium acremonium under less than Biosafety Level 
1-Large Scale (BL 1-LS) . 
The experiments envisaged could make a substantial 
scientific contribution to the success of our project and 
also provide results of considerable industrial value. In 
my view, they would be safe, for reasons that have already 
been listed by Eli Lilly. 
Yours sincerely 
Professor Sir Edward Abraham 
Dr William J Gartland Jr 
Director 
Office of Recombinant DNA Affairs 
12441 Park Lawn Drive Suite 58-1 
Rockville 
Maryland 20857 
USA 
[380] 
Recombinant DNA Research, Volume 13 
