PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR: Sandra Handwerger, M.D. 
Type the name of the Principal Investigator/Program Director at the top of each printed page and each continuation page. 
TABLE OF CONTENTS 
SECTION 1. 
PAGE NUMBERS 
Face Page, Description and Key Personnel, Table of Contents 1-3 
Detailed Budget for First 12-Month Budget Period 4 
Budget for Entire Proposed Project Period 5 
Budgets Pertaining to Consortium7Contractual Arrangements 
Biographical Sketch-Principal Investigator/Program Director (Not to exceed two pages) 
Other Biographical Sketches (Not to exceed two pages for each) 
Other Support 
Resources and Environment 
SECTION 2. Research Plan 
(Not to exceed 20 pages) 
Introduction to Revised or Supplemental application (Not to exceed one page). 
A. Specific Aims 
B. Background and Significance 
C. Progress Report/Preliminary Studies 
D. Experimental Design and Methods.. 
E. Human Subjects T 
F. Vertebrate Animals 
G. Consultants/Collaborators 
H. Consortium/Contractual Arrangements 
I. Literature Cited (Not to exceed four pages) . 
Checklist 
12 
.1TTZT 
14-17 
17-23 
23-32 
33-36 
37 
SECTION 3. Appendix (Six collated sets. No page numbering necessary for Appendix) 
Number of publications and manuscripts accepted for publication (Not to exceed ten): 
Other items (list): 
Appendix A: 
Figures 1 and 2 
[416] 
Recombinant DNA Research, Volume 13 
